Patients with certain KLK-6 mutations at risk for aggressive forms of prostate cancer

A newly published article in the Journal of the National Cancer Institute has suggested that men carrying a particular genetic mutation in the kallikrein 6 gene (KLK-6) have an increased risk for aggressive, clinically significant prostate cancer. … READ MORE …

Increasing our ability to predict who really needs to be biopsied

Data from a large study reported in the July issue of the Journal of the National Cancer Institute has confirmed the potential ability of a four-kallikrein marker test to lower the need for biopsies in men at risk for prostate cancer while delaying diagnosis of high-grade cancers in a few men. … READ MORE …

Do new, prospective data mean the 4KScore test is “proven” for use in prime time?

According to data from a large, prospective, multi-institutional trial carried out here in the USA, the 4KScore test has shown a high degree of ability to accurately identify men with a Gleason score of 3 + 4 = 7 or higher which was subsequently confirmed on prostate biopsy. … READ MORE …

OPKO Health, OURLab, and the 4Kscore test for prostate cancer risk

According to a media release on the company’s web site, OPKO Health has completed the acquisition of Prost-Data, Inc. (otherwise known to many prostate cancer patients and support group leaders — as well as their urologists — as Jonathon Oppenheimer’s independent uropathology company OURLab). … READ MORE …

The MSKCC-Malmö four-kallikrein model for prediction of prostate cancer risk

The collaborative research between the teams at Memorial Sloan-Kettering Cancer Center in New York and in Malmö in Sweden continues to  refine a model that may allow us to accurately predict which patients are at clinically significant risk for prostate cancer based solely on simple tests run on a single blood sample. … READ MORE …

A four-kallikrein panel and biopsy outcomes in previously untested men

In 2008, Vickers et al. initially proposed that a panel of four kallikrein markers, together with patient age, could potentially reduce the need for unnecessary biopsies in previously untested men with an elevated PSA level and a theoretical risk for prostate cancer. … READ MORE …

Prostate cancer news reports: Saturday, May 1, 2010

Today’s news reports include comments on studies dealing with:

  • A compound panel of markers for predicting risk for prostate cancer
  • Open vs. robot-assisted radical prostatectomy: urologists’ perceptions
  • Clinically relevant quality of life assessment after first-line therapy
  • A compound panel of markers for predicting overall survival of patients with CRPC … READ MORE …