Posted on December 18, 2020 by Sitemaster
Earlier today, the US Food and Drug Administration (FDA) approved relugolix, (Orgovyx, from Myovant Sciences), the first, oral luteinizing hormone releasing hormone (LHRH) receptor antagonist for the treatment of adult patients with advanced prostate cancer. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: antagonist, GnRH, LHRH, Myovant, Orgovyx, relugolix | 6 Comments »
Posted on June 1, 2020 by Sitemaster
The results of the Phase III HERO trial of relugolix — the first oral LHRH antagonist for treatment of advanced prostate cancer — have now been reported in the New England Journal of Medicine (NEJM) and at the “virtual” annual meeting of the American Society for Clinical Oncology (ASCO). … REAR MORE …
Filed under: Drugs in development, Living with Prostate Cancer, Management, Treatment | Tagged: antagonist, antiandrogen, HERO, LHRH, oral, relugolix, trial | 1 Comment »
Posted on April 22, 2020 by Sitemaster
According to a media release issued yesterday, Myovant Sciences (based in Basel, Switzerland) has submitted a New Drug Application (NDA) for approval of its oral LHRH antagonist, relugolix, in the treatment of men with advanced prostate cancer. … READ MORE …
Filed under: Drugs in development, Living with Prostate Cancer, Management, Treatment | Tagged: agonist, LHRH, Myovant, oral, relugolix | 2 Comments »
Posted on June 27, 2017 by Sitemaster
A poster presentation given the other day at the annual meeting of the Canadian Urological Association addressed the relative cardiovascular risks of LHRH agonist and antagonist therapies. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: agonist, antagonist, cardivascular, complication, LHRH, risk | Leave a comment »
Posted on October 28, 2016 by Sitemaster
Since 2007 a randomized clinical trial in the UK (the so-called PATCH trial) has been comparing the effectiveness and safety of transdermal estradiol patches to implants of an LHRH receptor agonist (goserelin acetate) in the treatment of advanced prostate cancer. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, agonist, androgen, deprivation, estradiol, LHRH, outcome, PATCH | Leave a comment »
Posted on April 28, 2016 by Sitemaster
A new paper from a panel of experts in the UK has suggested that the use of LHRH antagonists (e.g., degarelix) may be more appropriate than the use of LHRH agonists (e.g., leuprolide acetate of goserelin acetate) in some prostate cancer patients. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: agonist, antagonist, cardiovascular, LHRH, risk | 3 Comments »
Posted on February 9, 2016 by Sitemaster
Today’s news contained items that run the spectrum from the clinical value of tomatoes and lycopene via the cardiovascular side effects of LHRH agonists and antagonists to the question of whether proton beam radiation therapy is really cost-effective. So here are the “news shorts” for the day: … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Prevention, Risk, Treatment | Tagged: agonist, antagonist, cost-effectiveness, LHRH, lycopene, proton beam, PSA density, side effect, testosterone, tomato | 3 Comments »
Posted on December 1, 2014 by Sitemaster
One of our regular readers has asked us to comment on a paper suggesting the possibility of “significant improvement” in various outcomes for men initially treated with the LHRH antagonist degarelix as compared to the LHRH agonists leuprolide acetate and goserelin acetate. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: agonist, antagonist, benefit, Degarelix, LHRH, outcome, survival | 1 Comment »
Posted on January 20, 2014 by Sitemaster
At least three new LHRH receptor antagonists — i.e., drugs similar to degarelix (Firmagon) — are in development at the present time: elagolix, relugolix, and ASP-1707. However, unlike degarelix, all three are agents that would act as oral drugs as opposed to drugs one has to be given as long-term injections. … READ MORE …
Filed under: Drugs in development, Living with Prostate Cancer, Management | Tagged: antagonist, ASP-1707, elagolix, LHRH, oral, relugolix, TAK-385 | Leave a comment »
Posted on November 11, 2013 by Sitemaster
According to a survey of 75 Canadian physicians, there is a degree of disagreement among these physicians about what they should tell their patients about the side effects known to be associated with the use of LHRH agonists as a form of androgen deprivation therapy (ADT). … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: agonist, LHRH, side effects | 20 Comments »
Posted on April 8, 2013 by Sitemaster
The full text of a recent review on the use of LHRH receptor agonists (e.g., leuprolide acetate, goserelin acetate) asnd LHRH receptor antagonists (e.g., degarelix) has recently been published by Shore et al. in Prostate Cancer and Prostatic Diseases. The full text of the article is also available on line on the Medscape Oncology web site.
Filed under: Management, Treatment | Tagged: agonist, antagonist, LHRH, receptor, review | 3 Comments »
Posted on March 14, 2013 by Sitemaster
A study just published in European Urology suggests that — in addition to all the other side effects associated with LHRH receptor agonist therapy — such therapy also induces a small but statistically significant increase in risk for biliary disease. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: agonist, bile, biliary, gallstone, LHRH, risk | 3 Comments »
Posted on August 23, 2012 by Sitemaster
The “New” Prostate Cancer InfoLink is utterly unsurprised to learn about a forthcoming paper demonstrating that many men starting treatment with androgen deprivation therapy (ADT) — and their partners — are significantly under-informed about the risk for side effects and adverse effects associated with such therapy. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, adverse, androgen, deprivation, effects, LHRH, side | 10 Comments »
Posted on August 14, 2012 by Sitemaster
According to a corporate media release, a company called Spectrum Pharmaceuticals has initiated enrollment of an additional 150 patients into a Phase IIb trial of a new LHRH receptor antagonist called ozarelix (a drug with a similar mechanism of action to degarelix or Firmagon) for the treatment of advanced forms of prostate cancer. … READ MORE …
Filed under: Drugs in development, Management, Treatment | Tagged: antagonist, LHRH, ozarelix | 2 Comments »
Posted on August 15, 2011 by Sitemaster
The question of whether an LHRH antagonist (such as degarelix) is really a better first-line hormone therapy than an LHRH agonist (e.g., leuprolide acetate) is still not fully answered. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, agonist, androgen deprivation, antagonist, Degarelix, leuprolide, LHRH | Leave a comment »