Low-dose-rate brachytherapy monotherapy at the Mayo Clinic

A clinical research team from the Mayo Clinic (Routman et al.) has reported 10-year oncological results on 974 consecutive low- and intermediate-risk patients treated with low-dose-rate brachytherapy monotherapy (using iodine-125 seeds) from 1998 to 2013. … READ MORE …

After failure of first-line radiation, both kinds of salvage brachytherapy are equally effective

A group of researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) reported in 2014 (see this link) on the outcomes of 42 patients with radio-recurrent prostate cancer treated with salvage high-dose-rate brachytherapy (sHDR-BT). The results were quite good — … READ MORE …

Brachytherapy alone is enough for favorable intermediate-risk patients

RTOG 0232 was a large clinical trial conducted to determine whether low-dose-rate brachytherapy (LDR-BT) alone was of equal benefit compared to external beam radiation therapy with a brachytherapy boost (EBRT + LDR-BT) in intermediate-risk patients. … READ MORE …

Similar long-term outcomes after treatment with HIFU or LDR brachytherapy

The chances that we will ever see a large, randomized, comparative trial of high-intensity focused ultrasound (HIFU) and low-dose-rate (LDR) brachytherapy in the treatment of localized prostate cancer are near to zero. … READ MORE …

Low dose rate brachytherapy monotherapy across risk groups

New registry data from the Cleveland Clinic shows good oncological control with low dose rate brachytherapy (LDRBT) monotherapy, at least for low-risk and low  intermediate-risk groups. This is the first time I’ve seen LDRBT monotherapy data for higher-risk groups. … READ MORE …

EBRT + LDRBT boost provides superior cancer control compared to EBRT alone

Numerous retrospective analyses have suggested that the combination of external beam radiation therapy (EBRT) with a low-dose-rate brachytherapy (LDRBT) boost is highly effective in controlling prostate cancer in unfavorable-risk patients. … READ MORE …