A recently published meta-analysis and review in the journal European Urology is probably going to help an awful lot of urologic surgeons believe what they want to believe — that radical prostatectomy really is a better first-line treatment for localized prostate cancer than radiation therapy. The truth may be rather different. … READ MORE …
Filed under: Diagnosis, Management, Treatment | Tagged: conclusions, flawed, meta-analysis, radiation, surgery | 3 Comments »
Another paper at the European Cancer Congress this year has given us meta-analyses of data from studies of docetaxel chemotherapy + standard of care (i.e., some form of androgen deprivation therapy or ADT) in treatment of men newly diagnosed with metastatic (M1) and advanced but non-metastatic (M0) prostate cancer. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen, deprivation, docetaxel, meta-analysis, metastatic | 1 Comment »
According to the results from a new meta-analysis of data from 15 different clinical trials in nearly 7,000 patients in total, intermittent androgen deprivation therapy (ADT) is not inferior to continuous ADT with respect to the overall survival of patients. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen, continuous, deprivation, intermittent, meta-analysis | 2 Comments »
A new meta-analysis of data from nine large clinical trials suggests that, “There is fair evidence to recommend use of [intermittent] instead of [continuous androgen deprivation] for the treatment of men with relapsing, locally advanced, or metastatic prostate cancer who achieve a good initial response to androgen deprivation.” … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen, CADT, continuous, deprivation, IADT, intermittent, meta-analysis | 9 Comments »
A new meta-analysis has (once again) demonstrated that statin therapy does not appear to be associated with a survival benefit in men who have received first-line treatment for prostate cancer with surgery or radiation therapy. … READ MORE
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: meta-analysis, statin, Treatment | 2 Comments »
So a meta-analysis of data from multiple clinical trials has now shown rigorously something that we did, in fact, already know … that there was no excess incidence of cardiovascular mortality associated with androgen deprivation therapy (ADT) in clinical trials conducted to date in which use of ADT was compared to a placebo. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, androgen deprivation therapy, cardiovascular, meta-analysis, mortality, risk | 2 Comments »
Data from a meta-analysis of four, large, randomized, clinical trials of radiation therapy for locally advanced forms of prostate cancer suggests that radiation treatment lowers risk for metastasis and prostate cancer-specific mortality (PCSM), but that patient age at the time of treatment is a key factor too. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: meta-analysis, metastasis, outcome, radiation therapy, survival | 2 Comments »
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