Metformin + ADT in treatment of advanced prostate cancer

Yet another study, just published in the Journal of Urology, has indicated a clear association between the use of metformin along with androgen deprivation therapy (ADT) in the treatment of advanced forms of prostate cancer. … READ MORE …

Howard Wolinsky’s continuing patient journey

To quote Howard himself, “Not much on PC, but FYI.” But on the other hand, it is very much about the sometimes challenging aspects of “being a patient” — prostate cancer included. … READ MORE …

A potential downside to metformin in the treatment of men with diabetes

There have been suggestions for some time (but no confirmation yet from large scale clinical trials) that treatment with the antidiabetic agent metformin may be beneficial in the management of at least some forms of prostate cancer. However, … READ MORE …

Metformin + BI2536 may have significant activity in mCRPC

According to an new article in the Journal of Biological Chemistry, the combination of metformin with a polo-like kinase 1 (Plk1) inhibitor known currently as BI2536 appears to be able to suppress the spread of prostate cancer that resists all other available treatments. … READ MORE …

The potential of metformin in prostate cancer treatment: an update

We have previously commented (more than once) on the perception that metformin may have some value in the management of prostate cancer. A recently reported (albeit small), prospective Swiss study, has added to our knowledge in this regard. … READ MORE …

Potential of metformin in management of recurrent/progressive prostate cancer

A newly published, retrospective, epidemiological study has looked at the potential role of metformin the the management of prostate cancer in > 350 men already diagnosed and being treated for diabetes in the Shared Equal Access Regional Cancer Hospital (SEARCH) database. … READ MORE …

Can metformin extend survival of prostate cancer patients with (or without) diabetes?

A retrospective analysis of data from  > 3,800 Canadian men has suggested that diabetic men who also had prostate cancer and were being treated with a commonly used, generic drug called metformin have a reduced risk for death from prostate cancer. … READ MORE …

Neoadjuvant metformin in localized prostate cancer: not ready for prime time yet

A paper presented on Saturday at the annual meeting of the American Association for Cancer Research in Chicago has suggested the possibility of better outcomes after radical prostatectomy among men taking the diabetes drug metformin before their surgery … but the data are from a very small study. … READ MORE …

Metformin in the management of ADT-related side effects and morbidities

A newly published article in BJU International offers data from a small, randomized, pilot study of the use of metformin and lifestyle changes in the prevention of cardiovascular morbidity and androgen deprivation therapy (ADT)-related metabolic syndrome. … READ MORE …

The annual PCF “Creativity Awards”

Each year the Prostate Cancer Foundation gives out its “Creativity Awards” — intended to support research into new ideas with the potential to significantly affect the diagnosis and  treatment of prostate cancer. … READ MORE …