Adjuvant mitoxantrone + prednisone + ADT in treatment of high-risk prostate cancer

About 25 years ago the addition of the combination of mitoxantrone + prednisone to androgen deprivation therapy (ADT) was the first form of chemotherapy ever approved for the treatment of metastatic, castration-resistant prostate cancer. … READ MORE …

Is there ANY role for estramustine phosphate in treatment of CRPC today?

The appropriate, individual treatment of men with metastatic and non-metastatic forms of castration-resistant prostate cancer (CRPC) has become vastly more complicated over the past 5 years. … READ MORE …

IxMP as second- or third-line chemotherapy for mCRPC

A report on a Phase II study from the Department of Defense-funded Prostate Cancer Clinical Trials Consortium has suggested that ixabepilone + mitoxantrone + prednisone may have clinically significant activity as a form of second-line chemotherapy in the management of men with docetaxel-refractory, metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Cabazitaxel extends survival in Taxotere-refractory patients with CRPC

According to a media release from Sanofi-Aventis early this morning, the second-generation taxane cabazitaxel, when given in combination with prednisone, is capable of extending median survival by 2.4 months compared to mitoxantrone + prednisone in prostate cancer patients who are refractory to docetaxel (Taxotere) chemotherapy. … READ MORE …

Prostate cancer news reports: Saturday, July 18, 2009

In today’s news reports you will find items on:

  • Obesity and PSA levels
  • Outcomes after external beam radiation therapy
  • Mitoxantrone + predisone after taxotere failure … READ MORE …

Prostate cancer news reports: Friday, May 15, 2009

In today’s news reports we discuss:

  • Genetic abnormalities and intermediate risk prostate cancer
  • Ginger tablets to prevent chemotherapy-induced nausea
  • Ixabebilone + mitoxantrone in patients after Taxotere … READ MORE …