How accurate is an initial, negative prostate biopsy at predicting risk for prostate cancer-specific mortality?

A new paper in this week’s issue of Lancet Oncology comes from analysis of data on the outcomes of > 60,000 men given a prostate biopsy for risk of prostate cancer in Denmark between 1995 and 2011 and followed for up to 20 years thereafter. … READ MORE ..

Nadir PSA predicts survival after radiation and androgen deprivation for unfavorable risk patients

The following commentary addresses the article on risk for recurrent prostate cancer that we had mentioned briefly yesterday.

If a treatment isn’t working, we want to know as quickly as possible so we can try a salvage therapy while it can still make a difference. … READ MORE …

Prostate cancer statistics in America, 2017

As it does every year, the American Cancer Society (ACS) has just published it’s annual update cancer statistics update: Cancer Facts & Figures 2017. Those who are interested are of course welcome to peruse this detailed document for themselves. What follows is a quick summary of the prostate cancer-related data in the ACS update. … READ MORE …

And now … data from the PCLO trial at 15 years …

A new update on the prostate cancer outcomes of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial has given us a rather different interpretation of the meaning of the data from this trial — although whether that “meaning” actually has “meaning” is probably up for debate. … READ MORE …

The safety of treatment with statins (whether you have prostate cancer or not)

In a commentary a couple of days ago we noted some diversity among medical opinion leaders about the safety of treatment with statins. … READ MORE …

tPSA, cPSA, %fPSA and risk for diagnosis with and death from prostate cancer

Data from a series of > 1,200 Danish patients, all referred by their primary primary care physicians to a single, specialized urology practice, seems to confirm what has long been suspected about the relative values of total and complex PSA levels in the diagnosis of prostate cancer. … READ MORE …

Body mass index, surgery, and risk for prostate cancer-specific death

It is well understood that there is an association between obesity and future risk for prostate cancer-specific mortality among cancer-free men. What has not been so clear is the relationship between obesity and long-term outcomes, post-treatment, among men diagnosed early with localized disease … READ MORE …