Published data on activity of olaparib in some men with mCRPC

A paper in the New England Journal of Medicine now provides detailed information about the activity of the PARP inhibitor olaparib in the treatment of carefully selected patients with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Olaparib continues to show promise in very late stage prostate cancer

According to a presentation at the ongoing annual meeting of the American Association for Cancer Research (AACR) meeting here in  Philadelphia, AstraZeneca’s PARP inhibiting agent — olaparib or Lynparza — continues to show promise in very late stage metastatic, castration-resistant prostate cancer. … READ MORE …

Olaparib approved in the US (but not yet for prostate cancer)

On Friday this week the U.S. Food and Drug Administration approved a drug known as olaparib (Lynparza®) for the treatment of a very specific form of very late stage ovarian cancer. This may be of interest to some men with late-stage prostate cancer. … READ MORE …

Does olaparib have real potential in treatment of mCRPC?

According to a report on the Reuters web site yesterday, some researchers are of the opinion that the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (recently recommended for approval in Europe for the treatment of a subset of women with ovarian cancer) may be valuable in the treatment of some forms of prostate cancer too. … READ MORE …

Olaparib shows activity in advanced, BRCA1/2-positive prostate cancer

Apparently a drug known as olaparib (a so-called poly-ADP ribose polymerase or PARP inhibitor) has shown significant signs of activity against advanced prostate cancer in men who carry the BRCA1 and BRCA2 genes. … READ MORE …

All pumped up about PARPs

A report in this week’s issue of the New England Journal of Medicine (which is never shy about promoting itself) provides more early, and interesting, evidence of the future potential of so-called PARP inhibitors in cancer therapy. … READ MORE …