Orteronel active as “switch” maintenance therapy after docetaxel chemotherapy

According to a presentation given at the European Cancer Congress, currently ongoing in Vienna, Austria, a small, recently completed Phase III trial has shown that orteronel (TAK-700) might have had some value in treatment of late stage prostate cancer after all. … READ MORE …

Takeda discontinues development of orteronel for advanced prostate cancer

As previously reported, Takeda’s orteronel (also known as TAK-700), which had been in  Phase III clinical trials in metastatic, castration-resistant prostate cancer (mCRPC), failed to demonstrate a survival benefit in either of the two pivotal trials. … READ MORE …

Sunday morning’s news from the ASCO annual meeting

We commented earlier on several of the prostate cancer presentations given this morning at the American Society for Clinical Oncology (ASCO) meeting — see here and here. However, there was another important paper presented this morning. … READ MORE …

New Phase III trial is testing ADT + bicalutamide vs. ADT + TAK-700

It has been brought to our attention that the Southwest Oncology Group (SWOG) has initiated a new, randomized, double-blind, multi-center, Phase III trial designed to compare androgen deprivation therapy (ADT) + bicalutamide (Casodex) to ADT + the investigational drug TAK-700 in men newly diagnosed with metastatic, hormone-sensitive prostate cancer. … READ MORE …

Takeda completes enrollment of patients for pivotal Phase III trials of orteronel in mCRPC

Although the company has made no formal announcement, we have been advised that Takeda has, in fact, completed enrollment of patients into the two pivotal Phase III clinical trials of orteronel (TAK-700) for the treatment of patients with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Impact of abiraterone prior to chemotherapy — maybe not 4 years, but …

A story on the Bloomberg.com web site gives information about a patient with castration-resistant prostate cancer (CRPC) who has had a zero-level PSA for 40 months since starting on a clinical trial of abiraterone actetate in early 2008. … READ MORE …