For very high-risk patients, EBRT + BT is superior to surgery or EBRT only

A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT). … READ MORE …

Patient follow-up and care after first-line treatment for prostate cancer

Some of the most interesting data on the management of prostate cancer seem to be coming out of Australia in recent years — and the newly reported data from the ProCare trial is a case in point. … READ MORE …

RALP vs. ORP: data from a randomized Phase III clinical trial

A newly published paper in The Lancet has provided us with data from a randomized, Phase III, clinical trial of open radical retropubic prostatecomy (ORP) vs. robot-assisted laparoscopic prostatectomy (RALP) in the surgical treatment of localized prostate cancer. … READ MORE …

Defining value in the management of prostate cancer

Many years ago, among his other famous quotations on the subject of prostate cancer, Willet Whitmore, considered by many to be the “father” of urologic oncology, stated the following: … READ MORE …

Maybe PD-1 inhibitors have a role in advanced prostate cancer after all!

New immunotherapeutic drugs known as PD-1 inhibitors (drugs like nivolumab/Optivo and pembrolizumab/Keytruda) have shown some remarkable effects in the treatment of advanced forms of cancer like melanoma and some forms of lung cancer. … READ MORE …

Results we already knew about for cabozantinib in mCRPC

Back in September 2014, Exelixis had announced (and we had reported) the failure of the COMET-1 trial to show a meaningful survival benefit for treatment with cabozantinib in men with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Hypofractionated radiation therapy for localized prostate cancer: an update

Within the past year, we have reviewed several major randomized clinical trials comparing hypofractionated radiation therapy to conventionally fractionated radiation therapy for primary treatment of localized prostate cancer. … READ MORE …

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