The aggressive treatment of high-risk localized and node-positive prostate cancer

Long-term follow-up data have just been published from two studies designed to provide preliminary information on the potential use of very aggressive forms of treatment in men with high-risk categories of prostate cancer. … READ MORE …

Prostate cancer news reports: Wednesday, January 13, 2010

Today’s news reports summarize papers recently published on:

  • Optimism, pessimism, and long-term health outcomes
  • External beam radiation + hormone therapy for high-risk patients
  • Quality of life and health utility after radical prostatectomy
  • Paclitaxel + estradiol combination therapy in men progressing after docetaxel-based chemotherapy … READ MORE …

Adjuvant chemotherapy + ADT in high-risk patients after surgery

A number of trials are currently evaluating the potential value of adjuvant chemotherapy after first-line treatment in men with high-risk prostate cancer. The effects of this form of treatment on long-term outcomes still to be established, but … … READ MORE …

Neoadjuvant paclitaxel before surgery in high risk, locally advanced patients

A group at the Cleveland Clinic has reported the results of a small, single-arm, Phase II trial of neoadjuvant albumin-bound paclitaxel (nab-paclitaxel or neoadjuvant Abraxane®), given prior to radical prostatectomy in high risk, locally advanced patients. Prior comparable studies with neoadjuvant docetaxel have demonstrated a PSA response but have shown no obvious antitumor activity. … READ MORE …