When is radiopharmaceutical therapy most appropriately initiated in men with mCRPC?

A newly published paper by a team of Italian researchers has added a wrinkle to the critical questions about the most effective current and future forms of sequential therapy for men with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Single- vs. multi-fraction radiation therapy for metastatic, bone-related cancer pain

Data published in 2005 and later have clearly shown that — for most patients — single-fraction radiation therapy (e.g., a single dose of 8 Gy) is better than multi-fraction radiation therapy (e.g., 30 Gy given over 10 treatments) for the treatment of bone pain consequent to metastatic cancer that has spread into the bones (in prostate cancer and other forms of cancer). … READ MORE …

Pain still under-treated in many men with mCRPC (even at the best centers)

Back in the 1970s and 1980s, before the availability of the PSA test (with all its flaws and benefits), it used to be the case that pain was one of the commonest symptoms leading to a diagnosis of prostate cancer … because the majority of men only got diagnosed when they already had advanced, metastatic disease. … READ MORE …

FDA approves ExAblate technology to treat late stage bone pain

According to a media release issued yesterday, The U. S. Food and Drug Administration has approved a form of MRI-guided, focused ultrasound therapy for the treatment of pain associated with metastatic cancer to bone. … READ MORE …

Tamoxifen in prevention/management of gynecomastia and related, antiandrogen-induced side effects

According to a new, systematic review of data from four independently conducted clinical trials, tamoxifen may be the most effective agent for the management of breast events induced by treatment with non-steroidal antiandrogens (e.g., bicalutamide) in men with prostate cancer. … READ MORE …

Biopsy in D minor by Johann Sebastian you know who

A group of medical students and fellows at Duke University have shown that if you distract patients’ attention while they are having a prostate biopsy it can (at least to some extent) reduce the likelihood of patient reports of pain and anxiety associated with the procedure. … READ MORE …

Radionuclide therapy with strontium-89 for relief of metastatic bone pain

A new article on the OncologySTAT web site provides a summary of a presentation by Alain Pecking, MD, from the annual meeting of the International Society for Geriatric Oncology. … READ MORE …