Is Gleason pattern 5 resistant to adjuvant androgen deprivation therapy?

In a research study synthesis published in European Urology, Anthony D’Amico raises the hypothesis that androgen deprivation therapy (ADT) is most effective with Gleason pattern 4, but has lesser or no effect when prostate tumors include Gleason pattern 5. … READ MORE …

Heightened risk for prostate cancer among balding males (redux)

Back in 2014, Zhou et al. reported an association between baldness and risk for diagnosis with aggressive forms of prostate cancer. At the time we noted that this association really needed to be confirmed in other studies. … READ MORE …

Intraductal carcinoma of the prostate: of risk, outcomes, and Gleason scores

In a recent article in the American Journal of Surgical Pathology, Khani and Epstein have argued that patients initially diagnosed with intraductal carcinoma of the prostate (IDC-P) should have this reported as a separate class of prostate cancer, with no reference to the patients’ Gleason scores. … READ MORE …

Have reported patterns of Gleason scores changed significantly since 2005?

It has frequently been postulated that the recommendations of the International Society of Urological Pathology (ISUP) consensus meeting in 2005 would lead to a gradual “upgrading” of all pathologically evident prostate cancers. … READ MORE …

The distribution of bone mets in men with advanced prostate cancer

Those who are used to seeing the bone scans of men with advanced prostate cancer will have long realized that (usually) bone metastases seem to appear in a orderly manner over time: initially in the pelvis and lower spine, then up through the spine and out into the ribs and shoulders, and then out into the long bones of the arms and legs. … READ MORE …

Under-diagnosis of Gleason pattern 5 prostate cancer

The expertise of the pathologist assessing your prostate biopsy cores may make a major difference to the way you and your doctors think you need to be treated. Indeed the following data would suggest that many prostate biopsy samples should be examined by genitourinary pathologists who really specialize in prostate pathology. … READ MORE …

Should all “cribriform” prostate cancers be classified as Gleason 4 disease?

In recommendations made in association with a newly published study of the pathologiocal implications of “cribriform” prostate cancer tumors, Dr. Scott Lucia and colleagues are suggesting that all such tumors should be classified as Gleason grade 4 by definition. … READ MORE …