Patients who are initially diagnosed with primary Gleason pattern 5 localized prostate cancer (i.e., having Gleason scores of 5 + 5 = 10 and 5 + 4 = 9) are well understood to have very high-risk disease. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 5, Gleason, medicine, pattern, precision, risk | 3 Comments »
In a research study synthesis published in European Urology, Anthony D’Amico raises the hypothesis that androgen deprivation therapy (ADT) is most effective with Gleason pattern 4, but has lesser or no effect when prostate tumors include Gleason pattern 5. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: 5, Gleason, hypothesis, pattern | 7 Comments »
Back in 2014, Zhou et al. reported an association between baldness and risk for diagnosis with aggressive forms of prostate cancer. At the time we noted that this association really needed to be confirmed in other studies. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: baldness, male, mortality, pattern, risk | 5 Comments »
In a recent article in the American Journal of Surgical Pathology, Khani and Epstein have argued that patients initially diagnosed with intraductal carcinoma of the prostate (IDC-P) should have this reported as a separate class of prostate cancer, with no reference to the patients’ Gleason scores. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Gleason, grade, IDC-P, intraductal, Management, outcome, pattern, risk | 4 Comments »
It has frequently been postulated that the recommendations of the International Society of Urological Pathology (ISUP) consensus meeting in 2005 would lead to a gradual “upgrading” of all pathologically evident prostate cancers. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: Gleason, pattern, score, upstaging | 2 Comments »
The expertise of the pathologist assessing your prostate biopsy cores may make a major difference to the way you and your doctors think you need to be treated. Indeed the following data would suggest that many prostate biopsy samples should be examined by genitourinary pathologists who really specialize in prostate pathology. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: Gleason, pattern, under-diagnosis | 2 Comments »
In recommendations made in association with a newly published study of the pathologiocal implications of “cribriform” prostate cancer tumors, Dr. Scott Lucia and colleagues are suggesting that all such tumors should be classified as Gleason grade 4 by definition. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: cribriform, Gleason, pathology, pattern | 1 Comment »
We have known for a while that men with a tertiary Gleason grade of 4 or 5 (as discussed below) are at heightened risk for progressive forms of prostate cancer. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: Gleason, grade, pattern, prognosis, risk, tertiary | 1 Comment »
An interesting new report from the research team at Memorial Sloan-Kettering Cancer Center has explored the relationship between the patterns of occurrence of positive lymph nodes (LNs) and the topography of the cancer in the prostate and the seminal vesicles. … READ MORE …
Filed under: Management, Treatment | Tagged: lymph nodes, pathology, pattern, topography, tumor | Leave a comment »
It has long been understood that men with a Gleason score (GS) of 7 could be divided into two groups: those with Gleason 4 + 3 disease (in which Gleason pattern 4 was more common or “dominant”) and those with Gleason 3 + 4 disease (in which Gleason pattern 3 was dominant). … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: biochemical, Gleason, pattern, progression, risk, score | 5 Comments »
Barocas and Penson have offered a helpful new review of racial variation in the patterns and the quality of care offered to prostate cancer patients in the USA. The entire paper is available on line through the UroToday web site. … READ MORE …
Filed under: Living with Prostate Cancer, Management | Tagged: care, pattern, quality, race, variation | Leave a comment »
A review by Epstein in an upcoming issue of the Journal of Urology gives a detailed perspective on the current use of the Gleason grading system, with specific emphasis on the “removal” of Gleason patterns 1 and 2 in evaluating overall Gleason scores of biopsy samples and the value of “tertiary” Gleason pattern data. … READ MORE …
Filed under: Diagnosis, Management, Uncategorized | Tagged: Gleason, grade, modified, pattern, score, system | 8 Comments »
Burdick et al. have carried out a retrospective analysis of data from 705 patients with a pre-treatment biopsy Gleason score of 7 treated at the Cleveland Clinic between 1996 and 2005 to see if there was any difference in the outcomes of patients with a primary Gleason pattern of 3 (i.e., a Gleason score of 3 + 4 = 7) and those with a primary Gleason pattern of 4 (i.e., a Gleason grade of 4 + 3 = 7). Their data included men treated surgically and with different types of radiotherapy. … READ MORE …
Filed under: Management | Tagged: 3 + 4, 4 + 3, Gleason, grade, outcome, pattern | Leave a comment »
Today’s reports address:
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: cancer, Gleason, localized, news, pattern, prostate, radiotherapy, tertiary, update | Leave a comment »
THE "NEW" PROSTATE CANCER INFOLINK 