CRPC, “personalized” medicine, and the science of whack a mole

We have known for decades that prostate cancer is an “evolutionary” cancer. In other words, clinically significant prostate cancer and prostate cancer-specific mortality are the consequence of a series of events over time (probably both genetic and epigenetic) that lead to progressive and then to metastatic disease of variable levels of aggression. … READ MORE …

Just how helpful is personalized genomic analysis anyway?

Regular readers of the medical science literature will be very conscious of the emphasis on genomic analysis of tumor specimens as a way to try to “personalize” treatment of cancers of many types — prostate cancer very specifically included. … READ MORE …

Mouse “avatars” in the treatment of progressive cancers

We’re not sure what to make of this one at all, but apparently some people are now willing to pay to have pieces of their tumor transplanted into laboratory mice to test whether specific drugs will work on their tumor in those mice. … READ MORE …

Will CART-type treatments be usable to treat prostate cancer?

Many of our readers may be aware of what is known as “chimeric antigen receptor T-cell” therapy (often known as CART), and its development by Carl June and colleagues at the University of Pennsylvania over the past few years. … READ MORE …

“A plea for individualized prostate cancer screening”

For some years, Vickers, Lilja, and their associates have been arguing that baseline PSA level is able to predict long-term risk for prostate cancer, and now a new paper in European Urology seems to provide support for this argument and a practical clinical strategy for its application. … READ MORE …

Genetics, genomics, targeted therapy, and “personalized” cancer care

If you are still under the illusion that, simply by identifying the precise structure of the deoxyribonucleic acid (DNA) of patients’ cancer cells, we will be able to develop and target drugs that can eliminate specific cancers (or indeed other disorders) in specific individuals, an article by Sharon Begley on the Reuters.com web site should help to disabuse you. … READ MORE …