Exceptions to “early salvage” radiation treatment for recurrence after prostatectomy

Three major randomized clinical trials and a meta-analysis have proved that for most men waiting for early signs of recurrence after prostatectomy (e.g., three consecutive PSA rises or a PSA of 0.1 ng/ml) to give radiation gave the same outcome as immediate (“adjuvant”) radiation (see this link). But there are exceptions. … READ MORE …

Whole pelvic salvage radiation + short-term ADT improves oncologic outcomes

We didn’t expect to see data from the SPPORT trial for another 2 years, but the research team hit their recruitment goal early and have already been able to provide 5-year results. … READ MORE …

What should one do if one’s PSA remains detectable after radical prostatectomy?

After surgery, PSA should become “undetectable” on a normal PSA test (i.e., < 0.1 ng/ml) within a month or two, but sometimes it remains elevated. The primary purpose of the ARO 96-02 randomized clinical trial was to determine whether there was an advantage to treating stage T3-4N0 patients while PSA was still undetectable, or whether they could wait to be treated. … READ MORE …

The weekend news report: April 11, 2009

The concurrence of the Passover and Easter holidays this year appears to have limited medical science reports this weekend. There are really only two reports worth mentioning, and even they are of limited interest. … READ MORE …