Can the Decipher test accurately project risk for metastasis post-surgery?

A newly published article in the Journal of Clinical Oncology suggests that the Decipher test may be able to predict risk for metastatic prostate at 10 years post-surgery. However, … READ MORE …

Recovery of erectile/sexual function after surgical treatment for prostate cancer

A new review article in the journal Sexual Medicine Reviews has addressed current knowledge on the topic of penile rehabilitation after surgery for localized prostate cancer. … READ MORE …

High-risk patients get conflicting messages from radiation oncologists and urologists after first-line surgical treatment

In spite of data suggesting that brachy boost has better outcomes for high-risk patients, it is being utilized less often and surgery is being utilized more often. … READ MORE …

Can a dHACM allograft really improve sexual function post-surgery?

Our attention has been brought to a recent article suggesting that use of a “dehydrated human amnion/chorion membrane” (dHACM) allograft nerve wrap around the neurovascular bundle may help with recovery of erectile function post-surgery. … READ MORE …

Combining ADT and salvage radiation therapy improves outcomes

For the first time, a randomized clinical trial (GETUG-AFU 16) has proved that adding a short course of androgen deprivation therapy (ADT) to salvage radiation therapy (sRT) improves the progression-free survival over sRT alone. … READ MORE …

Declining trend in the utilization of adjuvant radiation after surgery

A recent report in European Urology found that, in spite of three randomized clinical trials (RCTs) that proved the efficacy of immediate or adjuvant radiation following surgery with adverse pathology results compared to a wait-and-see approach, a lower percentage of such patients are actually getting adjuvant treatment. Why should this be? … READ MORE …

Side effects of salvage radiation — difficult to draw conclusions based on database analyses

Two analyses of Italian and US databases have investigated whether delaying initiation of radiation therapy could diminish the side effects of radiation after prostatectomy. The conventional wisdom is that waiting longer allows the newly cut tissues more time to heal completely before the onslaught of radiation. … READ MORE …

Penile pain/urethral discomfort after radical prostatectomy

It comes as no surprise that there is some urethral “discomfort” experienced by patients with an indwelling urethral catheter after a radical prostatectomy (regardless of the type of surgery), and that for some patients there can be a degree of significant penile pain until the catheter is removed (usually within about 8 to 10 days). … READ MORE

Adding soy protein to your diet may NOT stop biochemical progression

According to data from a small, randomized, clinical trial published in the Journal of the American Medical Association, daily use of a supplement containing soy protein isolate for 2 years after radical prostatectomy did not reduce risk for biochemical progression of prostate cancer in high-risk patients. … READ MORE …

When is “immediate” adjuvant radiation therapy most appropriate after RP?

The appropriate use of “immediate” adjuvant radiation therapy after a man has a radical prostatectomy (RP) has long been controversial. Although a small number of clinical trials have attempted to address the relative benefits of adjuvant radiation as compared to salvage radiation (with and without additional androgen deprivation), there is still no real consensus. … READ MORE …

Adjuvant or salvage radiation for high-risk patients post-surgery? The need for shared decision-making

In the October issue of European Urology there was an interesting “consensus statement” about the role of radiation therapy as adjuvant or salvage therapy for men who are at significant risk for recurrence of their prostate cancer after first-line treatment with radical prostatectomy. … READ MORE …

Post-surgical enrollment in clinical trials by cancer patients

The national rates of participation in clinical trials by cancer patients have never been particularly high. The National Cancer Institute states that, “less than 5 percent of adults diagnosed with cancer each year will get treated through enrollment in a clinical trial.” … READ MORE …

Limited value of immediate, adjuvant ADT in men with pT3b prostate cancer

New data published by clinical researchers at the Mayo Clinic have suggested that there is no overall survival benefit associated with adjuvant hormone therapy after surgery in men with pathological T3b disease. … READ MORE …

Neuropathy in the lower extremities after RALP

The occurrence of  lower extremity neuropathies (pain in the lower parts of the legs) is a relatively uncommon but regularly reported side effect of robot-assisted laparoscopic radical prostatectomy (RALP) and also of robot-assisted radical cystectomy (RALC), which is the surgical removal of the bladder. … READ MORE …

Immediate adjuvant radiation therapy in the pT3 patient post-surgery

In March 2009, Thompson et al. published data from the SWOG 8794 trial showing that adjuvant radiation therapy immediately post-surgery significantly improved the oncologic outcomes of men with pathologic T3N0M0 prostate cancer compared to later salvage radiation, but … READ MORE …