Adjuvant mitoxantrone + prednisone + ADT in treatment of high-risk prostate cancer

About 25 years ago the addition of the combination of mitoxantrone + prednisone to androgen deprivation therapy (ADT) was the first form of chemotherapy ever approved for the treatment of metastatic, castration-resistant prostate cancer. … READ MORE …

Lower dosing of abiraterone acetate in treatment of elderly prostate cancer patients

A group of Italian clinicians and researchers have reported that low-dose abiraterone acetate along with very low-dose prednisone appears to be both effective and safe in the treatment of elderly patients between 85 and 93 years of age with castration-resistant prostate cancer (CRPC). … READ MORE …

Evaluating the risks and benefits of prednisone

Over the past 20 years or so, the oral corticosteroid prednisone has been used regularly in combination with drugs like mitoxantrone, docetaxel, cabazitaxel, ketoconazole, and abiraterone acetate in the treatment of men with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Adding dasatinib to docetaxel + prednisone does NOT improve OS in men with mCRPC

As one of our readers has already noted, a paper presented today at the Genitourinary Cancers Symposium did not report an overall survival benefit in the so-called READY trial. … READ MORE …

IxMP as second- or third-line chemotherapy for mCRPC

A report on a Phase II study from the Department of Defense-funded Prostate Cancer Clinical Trials Consortium has suggested that ixabepilone + mitoxantrone + prednisone may have clinically significant activity as a form of second-line chemotherapy in the management of men with docetaxel-refractory, metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Prostate cancer news reports: Wednesday, February 3, 2010

In today’s (slightly belated) news reports, we comment on studies dealing with:

  • A possible association between hypertension and later diagnosis of prostate cancer
  • Appropriate selection of high-risk patients for RALP
  • Optimization of the appropriate use of docetaxel + prednisone in  treatment of CRPC … READ MORE …

Prostate cancer news reports: Saturday, July 18, 2009

In today’s news reports you will find items on:

  • Obesity and PSA levels
  • Outcomes after external beam radiation therapy
  • Mitoxantrone + predisone after taxotere failure … READ MORE …