Neoadjuvant CHT + surgery for men with high-risk, localized prostate cancer

Eastham et al. have recently reported — in the Journal of Clinical Oncology — results from a randomized Phase III trial of the surgical treatment of men with high-risk forms of localized prostate cancer. … READ MORE …

ORP vs. RALP re-visited

A newly published report in The Lancet Oncology has pretty much finally confirmed what many of us have been assuming for a long time now: … READ MORE …

Is Retzius-sparing radical prostatectomy the surgical wave of the future?

Back in the early 1980s, Dr. Patrick Walsh at the Johns Hopkins Medical Center in Baltimore changed the nature of surgical treatment for prostate cancer when he first started to conduct so-called nerve-sparing radical prostatectomies. … READ MORE …

Pre-surgical weight loss in the surgical treatment of prostate cancer

Overweight and obese prostate cancer patients are often advised to lose weight prior to surgery for the treatment of localized forms of prostate cancer. But is this really, always, a good idea? … READ MORE …

Is salvage radical prostatectomy really being under-used?

A new paper in the journal Clinical Genitourinary Cancer states that, “Salvage radical prostatectomy (SRP) is a treatment modality for patients with radio-recurrent prostate cancer but is currently underutilized.” The “New” Prostate Cancer InfoLink is significantly less than convinced of that premise. … READ MORE …

Neoadjuvant chemotherapy prior to surgery in higher-risk patients

A combined Russian and German research team has provided some interesting preliminary information on the use of neoadjuvant, low-dose docetaxel-based chemotherapy in treatment of intermediate- and high-risk patients prior to radical prostatectomy. … READ MORE …

Expectation management and sexual/erectile outcomes after radical prostatectomy

A newly published paper in BJU International has helped to make clear that many surgical patients have unrealistic expectations about their recovery of erectile and sexual function after radical prostatectomy. … READ MORE …

Long-term survival of high-risk patients < 60 years of age treated by radical prostatectomy

A multi-institutional, international study has provided us with data on the 10-, 15-, and 20-year survival of a cohort of 600 relatively young, high-risk prostate cancer patients, all of whom were treated with first-line radical prostatectomy. … READ MORE …

Understanding the range of risks associated with prostate cancer surgery today

It would certainly be difficult (and arguably impossible) for us to provide a newly diagnosed prostate cancer patient with a  comprehensive list of all the possible side effects and complications that might be associated with every type of first-line treatment for prostate cancer. However, … READ MORE …

What everyone needs to expect about recovery post-surgery

Slowly but surely we are seeing increasing recognition in the clinical community of the need to ensure that prostate cancer patients and their spouses/partners really understand the likely consequences of treatment. … READ MORE …

Neoadjuvant ADT prior to radical surgery in high-risk prostate cancer patients

A group of South Korean researchers have just reported data on the prevalence and outcomes of pT0 disease after neoadjuvant androgen deprivation therapy (ADT) and radical prostatectomy among men receiving first-line therapy for high-risk prostate cancer. … READ MORE …

The side effects of radical prostatectomy: a new review

A new review article by a Danish research team in the Journal of Sexual Medicine has (arguably) brought a degree of clarity to what the authors refer to as “neglected” side effects consequent to radical prostatectomy. Unfortunately the average urologist probably doesn’t read the Journal of Sexual Medicine on a regular basis. … READ MORE …

Long-term impact on workplace status after radical prostatectomy

A recent Norwegian study has concluded that pre-surgical counseling of men electing treatment for prostate cancer by radical prostatectomy needs to include advice about risk for the possibility of post-surgical issues that may affect work status and their working life 3 years after their surgery. … READ MORE …

Robot-assisted versus open radical cystectomy: no clear signs of immediate benefit

Many readers of this blog have probably heard or read the reports like this one on the CBS Evening News or this one on the Reuters web site that there were no significant short-term (perioperative) differences in outcome between robot-assisted radical cystectomy (complete removal of the bladder) and the older open surgical procedure. … READ MORE …

The Radical Remission Project

So it is well known that some cancer patients — even (very occasionally) those with metastatic forms of prostate cancer — have what have commonly and historically been known as “spontaneous” remissions. Their apparently lethal cancers simply seem to “disappear”. Why? We really have very little idea! … READ MORE …