Radical prostatectomy: how much do YOU have to lose?

In a newly published paper in the Journal of Urology, researchers at the University of California, San Francisco have used data from CaPSURE to examine the relationship between age at surgery and quality of life pre- and post-surgery (for up to 2 years post-surgery). … READ MORE …

Whole-gland cryotherapy vs. radical prostatectomy as first-line treatment for localized disease

Over the years there have been very few studies that have attempted to make any type of direct comparison between outcomes of patients treated with whole-gland cryotherapy and outcomes of patients treated with other standard forms of whole gland therapy for localized prostate cancer. … READ MORE …

ORRP vs. RALP in a large cohort of high-risk patients with localized prostate cancer

A relatively large, retrospective, single-institution cohort study appears to show that oncologic outcomes after robot-assisted laparoscopic prostatectomy (RALP) are comparable to those achieved after open retropubic radical prostatectomy (ORRP) among high-risk patients when the operations are carried out by appropriately skilled and experienced surgeons. … READ MORE …

Different types of surgery for high-risk disease … outcomes at Johns Hopkins

In the context of the current question about “problems” with the da Vinci robot (previously addressed today), we have some new data from Johns Hopkins on the outcomes of men with high-risk, localized prostate cancer, treated using open, retropubic (ORP), non-robot-assisted laparoscopic (LRP), and robot-assisted laparoscopic (RALP) forms of radical prostatectomy. … READ MORE …

Risk for eye injuries associated with RALP for prostate cancer

One might reasonably be pardoned for not being able to imagine how having a radical prostatectomy with robot assistance (a robot-assisted laparoscopic prostatectomy or RALP) could possibly be associated with eye injuries, given the relative lack of proximity of the organs concerned. … READ MORE …

Long-term outcomes after RP as first-line therapy for men with cT3 disease at time of diagnosis

We have no data from randomized trials on the relative effectiveness of surgery compared to radiation therapy in the treatment of men initially diagnosed with clinical stage T3NxM0 prostate cancer. However, we do now have data from > 800 men treated with radical prostatectomy (RP) and followed for up to 23 years at the Mayo Clinic. … READ MORE …

Radical cystectomy as first-line treatment for clinical stage T4NxM0 prostate cancer

Clinical stage T4 prostate cancer is characterized by prostate tumors that have grown through the prostate capsule and into or even through the bladder wall. There is no agreed or “standard” form of first-line treatment for this form of localized prostate cancer. … READ MORE …

Robot-assisted surgery is not necessarily better than open surgery

As we regularly point out, outcomes after surgery for prostate cancer are massively impacted by the skill, the experience, and the focus of the surgeon. The tools he or she uses to carry out the surgery may or may not be a factor. We simply do not really know. … READ MORE …

How good are good “trifecta” data after surgery?

One of the constant questions that arises in the management of prostate cancer is just how many patients actually achieve the full “trifecta” (freedom from biochemical progression, pad-free continence, and good erectile function) after surgical treatment for localized disease. … READ MORE …

Does type of surgery make a difference to prostate cancer outcomes?

A new analysis of the outcomes of different types of radical prostatectomy appears to show no difference between the patients’ clinical outcomes following laparoscopic (including non-robot-assisted and robot-assisted) categories of surgery (LRP/RALP) and traditional “open” radical retropubic prostatectomy (RRP) when used to treat Medicare patients of 66 years or older. … READ MORE …

More weekend prostate cancer news: Sunday, August 17

Additional prostate cancer news this weekend includes the following items:

  • The role of follow-up pathology in patients with clinical stage T1a (TURP-detected) prostate cancer
  • The impact of the number of risk factors on the likelihood of prostate cancer-specific mortality in patients with intermediate- and high-risk disease
  • Whether a familial history of prostate cancer affects outcomes following brachytherapy for localized disease
  • Whether obese men are at greater risk for delayed diagnosis of prostate cancer and subsequent poorer outcomes based on current PSA screening recommendations … READ MORE …

The day’s news update: Thursday, August 14

Today’s prostate cancer news update includes information related to the following areas:

  • Long-term survival of patients with PSA levels ≥ 50 ng/mL who have been treated with radical prostatectomy
  • The current role of bone imaging in the managment of prostate cancer
  • The potential of targeted therapy for androgen-independent prostate cancer, based on expression of specific molecular markers … READ MORE …

Radical prostatectomy vs. watchful waiting: an update

Bill-Axelson et al. have just published an update of the Scandinavian Prostate Cancer Research Group’s prospective, randomized trial of watchful waiting vs. radical prostatectomy. The most recent results are somewhat worrisome.

For a detailed update on this study, please read the article entitled “Watchful waiting vs. radical surgery: the Scandinavian trial” elsewhere on this site. However, the crucial information is that at 10.8 years of follow-up there appears to have been no increase in the overall or the disease-specific survival benefit compared to the data at 8.2 years of follow-up.

More prostate cancer news: Tuesday, August 12

There are several interesting new papers reported today, and two very important ones (which have been addressed in separate posts). This post addresses:

  • A retrospective analysis of the relative predictive value of positive surgical margins following radical prostatectomy in the pre- and post-PSA eras
  • A new nursing model for management of urinary incontinence post-prostatectomy
  • The importance of assessing risk for transitional zone prostate cancer in patients already diagnosed with bladder cancer, and
  • A review of developing strategies for the treatment of late-stage prostate cancer
  • Other reports today address adjuvant vs. salvage radiation therapy and quality of care in management of early stage prostate cancer. … READ MORE …

All the prostate cancer news for Friday, August 8

Today’s news items all focus on issues that are closely connected to the recent and controversial  guidelines issued by the US Preventive Services Task Force:

  • The accuracy of current methods for predicting the likelihood of clinically insignificant (indolent) prostate cancer
  • The management of patients found to have incidental prostate cancer on treatment for benign prostatic hyperplasia (BPH), and
  • The risks of overtreatment of men in their 70s and 80s after a diagnosis of prostate cancer … READ MORE …