The end of a futile quest in management of localized prostate cancer?

Over the years, it has proved almost impossible to recruit patients to comparative trials of different types of first-line treatment in the management of localized prostate cancer — particularly in the USA. … READ MORE …

Calorie restriction as a treatment for progressive prostate cancer: a real clinical trial

For the first time ever — as far as anyone seems to be aware — a major cancer center will soon start to implement a controlled, randomized clinical trial of calorie restriction as a treatment for cancer. And they will be doing this trial in men with progressive prostate cancer. … READ MORE …

Kegel exercises, incontinence, training, and recovery of continence after RP

A new study just published in The Lancet has reported that  — among men who have urinary incontinence 6 weeks after a radical prostatectomy (RP) — formal one-on-one training of patients by expert therapists does not in fact reduce the rate of continence at 12 months compared to patients in a control group. … READ MORE …

Intermittent ADT “non-inferior” to continuous ADT in randomized Phase III trial

It has been suspected for many years that intermittent androgen deprivation (ADT) might have the same or a better impact on survival of prostate cancer patients as continuous ADT, with potentially superior effects on other factors such as quality of life. … READ MORE …

Results of a randomized trial of two modern types of radiation therapy

A newly published Italian study offers what we believe to be the first direct comparison of two “modern” types of external beam radiation therapy for the treatment of localized, high-risk prostate cancer. This is a relatively small trial, with relatively brief follow-up to date, but the results are nontheless interesting and important. … READ MORE …

QOL after cryotherapy vs. EBRT

Earlier this year we reported the initial results of a truly randomized Canadian trial of cryotherapy vs. external beam radiation therapy (EBRT) for the treatment of localized prostate cancer. The same group of authors have now reported follow-up data on quality of life. … READ MORE …

Radical prostatectomy vs. watchful waiting: an update

Bill-Axelson et al. have just published an update of the Scandinavian Prostate Cancer Research Group’s prospective, randomized trial of watchful waiting vs. radical prostatectomy. The most recent results are somewhat worrisome.

For a detailed update on this study, please read the article entitled “Watchful waiting vs. radical surgery: the Scandinavian trial” elsewhere on this site. However, the crucial information is that at 10.8 years of follow-up there appears to have been no increase in the overall or the disease-specific survival benefit compared to the data at 8.2 years of follow-up.