A paradigm for the future?

Not so long ago, one of the new immunotherapeutic agents (a PD-1 inhibitor called pembrolizumab or Keytruda) was approved by the US Food and Drug Administration (FDA) for the treatment of so-called microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) solid tumors — regardless of the biological site of origin of those tumors. … READ MORE …

Rare variants of adenocarcinoma of the prostate: a 25-year analysis of incidence and mortality

The vast majority of prostate cancers are adenocarcinomas of the prostate, i.e., cancers that start in the epithelial cells of the prostate gland. Most of these adenocarcinomas have a well-defined, “normal” cancer histology. However, there are five categories of rare adenocarcinoma, with differing levels of risk. … READ MORE …

Most prostate cancers aren’t rare diseases — but some are!

February 28, 2011 is Rare Disease Day — here in America and around the world. Sponsored by EURORDIS and by other national rare disease organizations (including the National Organization of Rare Disorders here in the USA), Rare Disease Day is held on the last day of February every year. … READ MORE …

Primary “signet ring cell” cancer of the prostate

“Signet ring cell” cancer of the prostate is a very rare and usually aggressive form of prostate cancer. It can occur in primary and secondary forms. … READ MORE …

The rare forms of prostate cancer

Mazzucchelli et al. have just published a sound and straightforward review discussing the rarer forms of prostate cancer, such as small cell carcinoma of the prostate, ductal adenocarcinoma, basal cell carcinoma of the prostate, and others. The entire paper is available on line and will be a useful resource for support group leaders, mentors, and others who help to inform, educate and support newly diagnosed patients.