New test for abiraterone- and enzalutamide-resistant forms of prostate cancer

A group at The Institute for Cancer Research and The Royal Marsden Hospital in the UK — along with other European colleagues — has come up with a new, relatively low-cost test that seems to be able to identify men with advanced forms of prostate cancer who are more or less likely to respond well to treatment with drugs like abirateone acetate and enzalutamide. … READ MORE …

Why inheriting a particular gene may be important for prostate cancer patients

An important poster that your sitemaster managed to “miss” at the recent ASCO meeting (because he was at another meeting while it was being presented) has just been discussed on the MedPage Today web site. … READ MORE …

And now … for the truly paranoid …

… a research letter in this week’s issue of JAMA Internal Medicine has real implications for anyone who spends significant time in a hospital … as a patient, as a healthcare professional, or just as someone visiting a patient. … READ MORE …

AR-V7 and resistance to treatment with enzalutamide, abiraterone

We have previously commented on early reports that prostate cancer patients carrying the androgen receptor subtype known as AR-V7 (the “isoform” encoded by splice variant 7) exhibit a high level of resistance to treatment with both enzalutamide (Xtandi) and abiraterone acetate (Zytiga). … READ MORE …

Risk for infection with ciprofloxacin-resistant E. coli at prostate biopsy today

A new paper in the Journal of Urology has concluded that standard universal antibiotic prophylaxis with ciprofloxacin can no longer provide optimal protection against Escherichia coli among men undergoing a transrectal ultrasound (TRUS)-guided prostate biopsy (at least in the Chicago area). … READ MORE …

Does type of exercise affect HRQoL in men on ADT for prostate cancer?

A newly published study in the Journal of Aging and Physical Activity has examined the differing effects of two types of exercise on the health-related quality of life (HRQoL) of men with prostate cancer who are being treated with androgen deprivation therapy (ADT). … READ MORE …

Does abiraterone acetate resistance induce cross-resistance to docetaxel-based chemotherapy?

A paper in the Annals of Oncology suggests that treatment with abiraterone acetate may induce a loss of effectiveness of docetaxel-based chemotherapy and that men with metastatic, castration resistant prostate cancer (mCRPC) who do not respond to abiraterone acetate will also not respond to docetaxel-based chemotherapy. … READ MORE …

Age, exercise, and ADT: effects on health and fitness in prostate cancer patients

While there is general consensus that exercise helps to minimize the impact of androgen deprivation therapy (ADT) on body composition, fitness, and other factors, there is limted evidence from clinical trials about the specific types of exercise that may be of greatest value. … READ MORE …

Exercise and radiotherapy: a controlled, randomized trial

It has long been known that external beam radiotherapy for treatment of prostate cancer may cause unfavorable changes in fatigue, quality of life (QOL), and physical fitness. This commentary discusses the results from the Prostate Cancer Radiotherapy and Exercise Versus Normal Treatment study, conducted in Canada. … READ MORE …