IMRT probably no better than 3D-CRT after radical prostatectomy

In another relatively unsurprising finding, a paper in JAMA Internal Medicine has suggested that– from a clinical point of view — there is little difference in the outcomes of men treated with older rather than newer forms of radiation therapy after first-line surgery for localized prostate cancer. … READ MORE …

Dutasteride as a second-line treatment for men failing first-line treatment for localized prostate cancer

New data from the ARTS study, reported in European Urology, suggests that dutateride may have a role in the treatment of men with biochemical failure after radical first-line therapy for prostate cancer. … READ MORE …

OncoGenex starts enrollment in new Phase III trial of custirsen

According to a media release from OncoGenex Pharmaceuticals earlier today, the company has started to enroll patients in a second, randomized, Phase III clinical trial of custirsen (OGX-011), this time in combination with second-line chemotherapy. … READ MORE …

Re-irradiation of the prostate after first-line radiation therapy for “localized” prostate cancer

The use of second-line radiation therapy following biochemical progression after first-line radiation therapy for localized forms of prostate cancer has long been limited by concerns about tolerance for rectal and related radiation toxicities. … READ MORE …

What different specialists believe about adjuvant radiation therapy

A recent study published in “The Red Journal” suggests (perhaps not surprisingly) that radiation oncologists and urologists have different mindsets about the application of immediate adjuvant radiation therapy following surgery for prostate cancer patients with a variety of adverse pathologic risk factors. … READ MORE …

High-dose bicalutamide as second-line hormone therapy in CRPC patients

Historically there have been few really compelling data available to support the use of an additional or alternative antiandrogen as a second-line agent to extend either progression-free or overall survival of castration-resistant prostate cancer (CRPC) patients who progress after first-line hormone therapy (whether they have been treated by orchiectomy or medical castration with an LHRH agonist). … READ MORE …

Nitroglycerin for the treatment of progressive prostate cancer?

According to a group of researchers at Queen’s University in Kingston, Ontario, a very low dose of nitroglycerin may be able to delay the progression of prostate cancer in men with a rising PSA after standard first-line treatment with radiotherapy or surgery. … READ MORE …

Prostate cancer news reports: Tuesday, June 23, 2009

Today’s news reports address items on:

  • Outcomes from different types of radical prostatectomy
  • Radiation therapy in patients > 80 years of age
  • Paclitaxel-based, second-line chemotherapy
  • Prostate and other cancers in transplant patients … READ MORE …