Selenium rising … all over again

As some of our older readers will remember, there was a major Phase III clinical trial several years ago (the SELECT trial) designed to study whether taking regular selenium supplements could help to lower risk for a diagnosis of prostate cancer. It didn’t. … READ MORE …

Lycopene, selenium, GTCs, and (maybe?) the prevention of prostate cancer — or maybe not

There have really been very few meaningful, randomized, double-blind trials of any forms of supplement in the prevention of prostate cancer … and to date none of the trials that have been done have shown unarguably meaningful, positive results. … READ MORE …

Time for men to stop taking OTC vitamin E and selenium supplements

According to a media release issued by the Fred Hutchinson Cancer Research Center late last Friday, “high-dose supplementation with both the trace element selenium and vitamin E increase the risk of high-grade prostate cancer.  But importantly, this risk depends upon a man’s selenium status before taking the supplements.” … READ MORE …

Selenium levels in tissue and prostate cancer risk

According to a paper presented yesterday by Geybels et al. at the ongoing annual meeting of the American Association for Cancer Research in Washington, DC, among almost 60,000 men aged 55 to 69 at the beginning of the study, the men with the highest levels of selenium in their toenail clippings were 60 percent less likely to develop advanced prostate cancer. … READ MORE …

Back to the question of whether selenium levels affect prostate cancer risk

A newly published review and meta-analysis in The American Journal of Clinical Nutrition has suggested that biological levels of selenium that fall outside a relatively narrow “normal” range may well be associated with increased risk for prostate cancer. … READ MORE …

Selenium in treatment of men with HG-PIN to prevent prostate cancer

The SELECT study has previously shown that treatment with selenium did not prevent prostate cancer in your average “guy in the street.” However, what about men with a prior diagnosis of high-grade prostatic intraepithelial neoplasia (HG-PIN)? … READ MORE …

Selenium, vitamin E, soy, and prostate cancer prevention

A new Canadian study just reported in the Journal of Clinical Oncology has failed to find any significant benefit from the use of vitamin E, selenium, and soy protein supplements in the prevention of prostate cancer. … READ MORE …

Can selenium therapy prevent prostate cancer in men with HG-PIN?

We know from the results of the SELECT study that selenium therapy does not prevent prostate cancer in men in general. However, a smaller and separate trial has been studying whether selenium may be able to prevent prostate cancer in men with a biopsy-based diagnosis of high-grade prostatic epithelial neoplasia (HG-PIN), … READ MORE …

Is there a link between genetics, selenium, and prostate cancer risk?

A new article in Cancer Prevention Research not only suggests the possibility that there is a very real association between selenium levels in serum after all, but it also helps to explain why this association may not have shown up in the large, double-blind, and randomized SELECT trial. … READ MORE …

Risks from selenium — in men WITH prostate cancer

A recent study from researchers at the University of California, San Francisco and the Dana-Farber Cancer Center is now suggesting that elevated selenium levels in the blood may worsen prostate cancer outcomes in some men who already have the disease. … READ MORE …

Prostate cancer news reports: Friday, June 26, 2009

Today’s prostate cancer news report summary includes items dealing with:

  • The epigenetics of prostate cancer and their potential importance
  • Selenium + vitamin E + lycopene (in mice)
  • Gleason 7: 4 + 3 versus 3 + 4 — it’s important
  • Proton beam radiotherapy — a topical review
  • EBRT + low dose, permanent seed brachytherapy … READ MORE …

A sudden squall about selenium

Apparently the Center for Science in the Public Interest (CSPI) “is threatening to sue” Bayer HealthCare “for ‘misleading men’ about the benefits of” two of its selenium-containing One-A-Day products, … READ MORE …

The news report: Friday, April 24, 2009

In today’s news report we touch on papers that address:

  • Genome studies and identification of real genomic risk for prostate cancer
  • More on the potential of 5-ARIs in prevention of prostate cancer
  • Whether we really need more studies on selenium as a potential prostate cancer prevention agent
  • The evolving potential of targeted focal therapy … READ MORE …

Supplements and prostate cancer prevention: an update

An article by Collins on the CalorieLab web site offers a sound summary of “where we are” (or perhaps more accurately “where we aren’t”) with regard to the use of supplements in the prevention of prostate cancer. … READ MORE …

Early weekend news: Saturday, December 20, 2008

There are only three notable reports in today’s news stream … but one of them may be very important (if you can understand it) … … READ MORE …