Patient-reported outcomes and quality of life in the ProtecT trial

We have already commented on the oncologic outcomes of patients enrolled in the ProtecT trial and published in today’s issue of the New England Journal of Medicine. In this commentary we shall comment on the separate paper that addresses patient-reported outcomes from that trial. … READ MORE …

Risk for hospitalization after surgery or radiation therapy for localized prostate cancer

According to a newly published article in BJU International, there was little to no major difference in the risks for hospitalization within 1 year after first-line treatment among relatively healthy, Medicare-eligible men with localized prostate cancer treated by either radical surgery or radiation therapy. … READ MORE …

Adverse events of primary, intensity-modulated radiation therapy (IMRT)

In a recent commentary, the Sitemaster mentioned some common adverse effects of radical prostatectomy, some of which (e.g., perceived penile shrinkage, climacturia) are seldom mentioned by urologists to prospective patients, and are not routinely included in standardized quality-of-life questionnaires. … READ MORE …

Understanding the range of risks associated with prostate cancer surgery today

It would certainly be difficult (and arguably impossible) for us to provide a newly diagnosed prostate cancer patient with a  comprehensive list of all the possible side effects and complications that might be associated with every type of first-line treatment for prostate cancer. However, … READ MORE …

HDRBT monotherapy in treatment of high-risk prostate cancer

Three randomized clinical trials (Sathya et al., 2005; Hoskin et al., 2012; and Guix et al., 2013) established the combination of external beam radiation therapy (EBRT) with a high dose rate brachytherapy (HDRBT) boost as a standard of care in the treatment of high-risk prostate cancer. … READ MORE …

Cardiovascular side effects and the early use of ADT — another large data set analysis

A newly published paper in BJU International has expanded our understanding of the cardiovascular risks associated with the use of androgen deprivation therapy (ADT) — most particularly in older men treated with ADT as their first-line form of therapy. … READ MORE …

The side effects of radical prostatectomy: a new review

A new review article by a Danish research team in the Journal of Sexual Medicine has (arguably) brought a degree of clarity to what the authors refer to as “neglected” side effects consequent to radical prostatectomy. Unfortunately the average urologist probably doesn’t read the Journal of Sexual Medicine on a regular basis. … READ MORE …