The APCCC in Basel, Switzerland: Day 2

The second day of the APCCC here in Basel ran for 10 hours and encompassed a total of six sessions, as follows: … READ MORE …

A prostate cancer book that is uniquely useful

There is a large number of books for patients that deal with a diagnosis and management of prostate cancer. However, there is a relatively small number of books that are really valuable for a large number of men (and their partners) who have to deal with a diagnosis of prostate cancer. Very few books on prostate cancer ever make it into a second edition. … READ MORE …

Outcomes, side effects, quality of life, and choosing a treatment that works FOR YOU!

Three articles in this week’s Journal of the American Medical Association throw a little more light on issues related to quality of life after diagnosis and treatment for localized prostate cancer … but quite how much light it is difficult to tell. … READ MORE …

Is once ever enough (in prostate radiation therapy)?

When Jeff Demanes at the California Endocurietherapy Center, then in Oakland, CA, started doing high-dose-rate brachytherapy (HDR-BT) as a monotherapy (i.e., without any additional external beam therapy or hormone therapy), he arbitrarily chose a treatment schedule of 42 Gy delivered in six treatments or fractions. … READ MORE …

Patient-reported outcomes and quality of life in the ProtecT trial

We have already commented on the oncologic outcomes of patients enrolled in the ProtecT trial and published in today’s issue of the New England Journal of Medicine. In this commentary we shall comment on the separate paper that addresses patient-reported outcomes from that trial. … READ MORE …

Risk for hospitalization after surgery or radiation therapy for localized prostate cancer

According to a newly published article in BJU International, there was little to no major difference in the risks for hospitalization within 1 year after first-line treatment among relatively healthy, Medicare-eligible men with localized prostate cancer treated by either radical surgery or radiation therapy. … READ MORE …

Adverse events of primary, intensity-modulated radiation therapy (IMRT)

In a recent commentary, the Sitemaster mentioned some common adverse effects of radical prostatectomy, some of which (e.g., perceived penile shrinkage, climacturia) are seldom mentioned by urologists to prospective patients, and are not routinely included in standardized quality-of-life questionnaires. … READ MORE …

Understanding the range of risks associated with prostate cancer surgery today

It would certainly be difficult (and arguably impossible) for us to provide a newly diagnosed prostate cancer patient with a  comprehensive list of all the possible side effects and complications that might be associated with every type of first-line treatment for prostate cancer. However, … READ MORE …

HDRBT monotherapy in treatment of high-risk prostate cancer

Three randomized clinical trials (Sathya et al., 2005; Hoskin et al., 2012; and Guix et al., 2013) established the combination of external beam radiation therapy (EBRT) with a high dose rate brachytherapy (HDRBT) boost as a standard of care in the treatment of high-risk prostate cancer. … READ MORE …

Cardiovascular side effects and the early use of ADT — another large data set analysis

A newly published paper in BJU International has expanded our understanding of the cardiovascular risks associated with the use of androgen deprivation therapy (ADT) — most particularly in older men treated with ADT as their first-line form of therapy. … READ MORE …

The side effects of radical prostatectomy: a new review

A new review article by a Danish research team in the Journal of Sexual Medicine has (arguably) brought a degree of clarity to what the authors refer to as “neglected” side effects consequent to radical prostatectomy. Unfortunately the average urologist probably doesn’t read the Journal of Sexual Medicine on a regular basis. … READ MORE …

Side effects of salvage radiation — difficult to draw conclusions based on database analyses

Two analyses of Italian and US databases have investigated whether delaying initiation of radiation therapy could diminish the side effects of radiation after prostatectomy. The conventional wisdom is that waiting longer allows the newly cut tissues more time to heal completely before the onslaught of radiation. … READ MORE …

Supervised exercise and prevention of ADT-related side effects

A small, randomized trial in a group of 60+ Australian patients has demonstrated that a supervised exercise program started at the same time as initiation of androgen deprivation therapy (ADT) can have multiple beneficial results, including (at least temporary) avoidance of known side effects of ADT. … READ MORE …

Follow-up to earlier commentary on the Michigan Prostate Cancer Survivor study

Late last week we commented briefly on a paper (by Darwish-Yassine et al.) entitled “Evaluating long-term patient centered outcomes following prostate cancer treatment: findings from the Michigan Prostate Cancer Survivor study.” … READ MORE …

Long-term quality of life and survivorship issues for prostate cancer patients

There are very few really good data available on the long-term follow-up of men diagnosed and treated for prostate cancer outside a select group of specialized prostate cancer centers (with the notable exception of the data collected as part of the CaPSURE initiative). … READ MORE …