NICE rejects clinical use of denosumab in men with metastatic prostate cancer

In the UK, the National Institute for Clinical Excellence has announced revisions to its initial, draft recommendation on the clinical use of denosumab (Xgeva®) for the treatment of people with cancer that has metastasized to the bones. … READ MORE …

Denosumab approved in Europe for treatment of SREs

Denosumab (Xgeva®) has been approved by the European Medicines Agency (EMEA) for the prevention of skeletal-related events (SREs) in adults with bone metastases from solid tumors, including prostate cancer, according to a media release issued by Amgen last Friday. … READ MORE …

US FDA approves Xgeva for prevention of “skeletal-related events”

According to a media release from Amgen, issued late yesterday, the US Food & Drug Administration (FDA) has approved denosumab (to be known by the brand name Xgeva™) for “prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors.” This indication would include patients with prostate cancer and evident bone metastasis. … READ MORE …

Featured in “day 1” at the ASCO annual meeting

Saturday was never going to be a major day for prostate cancer at the annual meeting of the American Society for Clinical Oncology (ASCO) here in Chicago. … READ MORE …

Is denosumab “better” than Zometa at preventing skeletal events?

Amgen, the developer of denosumab (also known as RANK-L) has released data today from a head-to-head trial of their drug vs. zoledronate (Zometa) in the management of patients with advanced breast cancer and bone metastases. … READ MORE …

The weekend prostate cancer news: Saturday, January 31, 2009

Items covered in this weekend news report include:

  • Acrylamide exposure as a potential risk for prostate cancer
  • The relative merits of three standard first-line therapies in intermediate risk prostate cancer
  • Estramustine + etopside in hormone-refractory prostate cancer (HRPC)
  • Bone turnover markers and risk for skeletal-related events in patients receiving zoledronic acid … READ MORE …