The first-line treatment of locally advanced prostate cancer (clinical stage T3)

Does radical prostatectomy (with or without external beam radiation therapy) improve prostate-cancer specific survival by comparison with primary radiation treatment and androgen deprivation therapy (ADT) among patients initially diagnosed with locally advanced (T3) prostate cancer? … READ MORE …

Salvage whole pelvic radiation after cancerous pelvic lymph nodes have been found

Is it still worthwhile to attempt salvage radiation therapy (SRT) after positive pelvic lymph nodes (PLN) have been pathologically detected (stage pN1)? … READ MORE …

Risk, prostate cancer, and being 70 to 80 years of age

So a relatively new article in Reviews in Urology caught your Sitemaster’s eye this morning — and worried him because it seemed to be communicating a conclusion of questionable accuracy, which we will explore below. And if we have misinterpreted the data provide in the paper, we are more than willing to be corrected. … READ MORE …

Test your knowledge on the diagnosis and staging of prostate cancer

Support group leaders and other prostate cancer educators may wish to test their knowledge on the diagnosis and staging of prostate cancer by reading through the set of 29 slides prepared by Kleynberg and Gross and just made available on the Medscape web site.

A real decrease in the use of RP in treatment of men with low-risk prostate cancer?

A new paper from clinical research teams at two French hospitals suggests that there has been a significant relative increase (from 2005 to 2010, at their institutions) in the percentage of men found to have pathological T3 as opposed to pathological T2 disease after radical prostatectomy (RP). … READ MORE …

The current state of focal therapy for localized prostate cancer

Many readers may be interested in two expert interviews on the OncologySTAT web site with Dr. Mark Emberton (a member of the Scientific Advisory Board of The “New “Prostate Cancer InfoLink). … READ MORE …

Long-term outcomes after RP as first-line therapy for men with cT3 disease at time of diagnosis

We have no data from randomized trials on the relative effectiveness of surgery compared to radiation therapy in the treatment of men initially diagnosed with clinical stage T3NxM0 prostate cancer. However, we do now have data from > 800 men treated with radical prostatectomy (RP) and followed for up to 23 years at the Mayo Clinic. … READ MORE …

Radical cystectomy as first-line treatment for clinical stage T4NxM0 prostate cancer

Clinical stage T4 prostate cancer is characterized by prostate tumors that have grown through the prostate capsule and into or even through the bladder wall. There is no agreed or “standard” form of first-line treatment for this form of localized prostate cancer. … READ MORE …

Excess deaths among some older men with prostate cancer

A population-based analysis of mortality data for men diagnosed with prostate cancer from three European nations suggests that “a small but important group of older patients” initially present with late stage prostate cancer and die rapidly as a consequence. … READ MORE …

Clinical and pathologic staging of localized prostate cancer: an update

A new review by Epstein, currently available on line in the Journal of Urology, provides a detailed analysis of the clinical significance of various factors in determining prognostic risk for newly diagnosed and recently treated patients with localized prostate cancer. … READ MORE …

Surprise! Being married improves prostate cancer survival

It has been known for years that marital status impacts the likelihood of stage at diagnosis and survival in a number of different types of cancer (prostate cancer included). However, a new study has now confirmed this in a large, US, population-based analysis of prostate cancer patients. … READ MORE …

Prevalence of men with differing stages of prostate cancer in the USA

One of the posters to be presented at the upcoming annual meeting of the American Society of Clinical Oncology offers an interesting model permitting replicative estimation of the numbers of patients living with different clinical stages of prostate cancer. … READ MORE …

“Reverse stage shift” at major tertiary prostate cancer center since 2000

Exactly how some of the major, tertiary, specialized prostate cancer centers think about the management of prostate cancer over time needs to be taken into account in evaluation of the data being published by those centers. … READ MORE …

Accuracy and relevance of clinical stage in diagnosis and prognosis of localized prostate cancer

According to a new report from the University of California, San Francisco (to be published in Cancer this week), clinical staging errors may — at least in part — underlie the fact that the researchers were unable to demonstrate a clear link between clinical stage and risk for prostate cancer recurrence in patients initially diagnosed with localized prostate cancer. … READ MORE …

Fewer lymph node dissections and fewer positive lymph nodes: does it actually matter?

Surgical removal of samples of the pelvic lymph nodes at the time of radical prostatectomy (RP) — known as pelvic lymph node dissection (PLND)  — is still the most accurate method available to determine the presence or absence of lymph nodes positive for cancer (pN1 disease) in a patient with cancer of the prostate. … READ MORE …