SBRT vs. standard IMRT as first-line radiation therapy for localized prostate cancer

Many readers may be interested in an article by Gina Kolata in today’s issue of The New York Times. It deals with the rising popularity of stereotactic body radiation therapy (SBRT) in the management of localized prostate cancer. … READ MORE …

SBRT vs. moderate hypofractionation: same or better quality of life?

In several randomized clinical trials of external beam treatment of primary prostate cancer, we have seen that moderately hypofractionated intensity-modulated radiation therapy (HypoIMRT), accomplished in 12 to 26 treatments or fractions, is no worse than conventionally fractionated IMRT treatment (in 40 to 44 fractions). … READ MORE …

Toxicity equal for SBRT and conventional external beam radiation (3D-CRT)

There has been some question as to whether the toxicity of delivering very high doses of external beam radiation per treatment (or fraction) in fewer fractions (called “extreme hypofractionation” or SBRT) would be high compared to conventional dose rates per fraction. … READ MORE …

5-Year SBRT trial: high cancer control, low toxicity

Data from a 5-year-long, multi-institutional trial, reported at the recent ASTRO meeting, showed that stereotactic body radiation therapy (SBRT) had high rates of cancer control and low toxicity. … READ MORE …

Safety limits of SBRT dose escalation

In a recent commentary, we saw that the lack of a standard of care for stereotactic body radiation therapy (SBRT) dose escalation may put patients at risk when dose limits are pushed beyond what is customarily considered effective and safe. … READ MORE …

SBRT boost radiation therapy in intermediate- and high-risk prostate cancer

Recently we have seen evidence of improved cancer control in high-risk patients treated with external beam radiotherapy with a brachytherapy boost to the prostate. This has been demonstrated with both HDR brachytherapy boost and with LDR brachytherapy boost. … READ MORE …

Salvage SBRT for local recurrence after first-line (primary) radiation therapy

This is the second part of a two-part commentary. In the first part, we looked at studies that identified the site of failure after primary radiation treatment, … READ MORE …