Surgical orchiectomy vs. medical castration in treatment of metastatic prostate cancer

A new study in JAMA Oncology has suggested that surgical orchiectomy may have lower risk for complications and side effects than medical castration with LHRH agonists (also known as GnRH agonists) like leuprolide acetate (Lupron) and others in treatment of men newly diagnosed with metastatic prostate cancer. This is a complex issue! … READ MORE …

If you have positive surgical margins post-surgery, you need to …

… know the Gleason score of the tissue at that positive surgical margin as well as and as opposed to just the Gleason score of the primary tumor. It makes a difference to your risk for biochemical recurrence. Your doctors need to know this information too! … READ MORE …

Which patients with a PSM post-surgery need early adjuvant therapy?

Could more intensive monitoring of PSA levels in the first few months after a radical prostatectomy help to determine which patients who have a positive surgical margin (PSM) need adjuvant radiation therapy and which don’t? … READ MORE …

Should we be calling “hormone therapy” for prostate cancer a spade?

When women and their doctors talk about “hormone therapy” they are most commonly referring to the (now) highly controversial issue of whether hormonal supplements (estrogen and progesterone) should be used at and after menopause to prevent the symptoms of menopause and/or later risks related to heart disease and osteoporesis. … READ MORE …

Hospital volume important to outcomes among older, sicker, Medicare patients treated by RP

A media release issued by Henry Ford Health System earlier today has a distinctly misleading headline that reads as follows: “Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery.” You need to read the content of the media release with care to understand that this headline is by no means an accurate summation of the results of the study referred. … READ MORE …

Is a PSM an independent predictor of risk for disease progression?

A study just published by Sæther et al. appears to suggest that the clinical finding of a positive surgical margin (PSM) is not an important independent predictor for risk of progression when compared to other data available at the time of surgery. … READ MORE …

More prostate cancer news: Tuesday, August 12

There are several interesting new papers reported today, and two very important ones (which have been addressed in separate posts). This post addresses:

  • A retrospective analysis of the relative predictive value of positive surgical margins following radical prostatectomy in the pre- and post-PSA eras
  • A new nursing model for management of urinary incontinence post-prostatectomy
  • The importance of assessing risk for transitional zone prostate cancer in patients already diagnosed with bladder cancer, and
  • A review of developing strategies for the treatment of late-stage prostate cancer
  • Other reports today address adjuvant vs. salvage radiation therapy and quality of care in management of early stage prostate cancer. … READ MORE …