Prostate cancer statistics in America, 2017

As it does every year, the American Cancer Society (ACS) has just published it’s annual update cancer statistics update: Cancer Facts & Figures 2017. Those who are interested are of course welcome to peruse this detailed document for themselves. What follows is a quick summary of the prostate cancer-related data in the ACS update. … READ MORE …

ADT + sipuleucel-T in treatment of hormone-sensitive prostate cancer

One of the major unanswered questions at this time is whether immunotherapy of some type, if given early to patients with prostate cancer, can help to lower risk of progression of the disease. … READ MORE …

Outcomes, survival, and HRQOL in trials of new drugs (and what they mean in practice)

A new paper in the journal Quality of Life Research has raised the question of whether it is possible to use available quality of life data from Phase III trials of new drugs in the treatment of advanced prostate cancer to make rational decisions about the use of those drugs in clinical practice. … READ MORE …

Is a possible benefit from longer-term docetaxel-based chemotherapy real?

A new paper in JAMA Oncology has suggested that longer docetaxel-based chemotherapy may be associated with longer survival for at least some men being treated for metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Nuts to the Daily Telegraph … and nuts for most of our readers!

Finally, we may have the perfect paper that illustrates the critical difference between overall mortality rates and cancer-specific cancer rates among men with prostate cancer, and how affecting one may have no effect whatsoever on the other! … READ MORE …

Is overall survival a useful endpoint for evaluating therapies for intermediate-risk patients?

In a recent commentary, we looked at the utility of surrogate endpoints in evaluating therapies. … READ MORE …

Dose-escalated radiation therapy doesn’t impact survival within 10 years

Zaorsky et al. conducted a meta-analysis of 12 randomized clinical trials covering data on 6,884 patients treated with external beam radiation at various dose levels. … READ MORE …

Statin therapy lowers mortality rates among Danish prostate cancer patients

According to a media release and a presentation given at the European Association of Urology (EAU) in Europe this week, statin therapy has a small but significant impact on overall and prostate cancer-specific mortality rates. … READ MORE …

Site of prostate cancer metastasis and length of patient survival

There has long been information suggesting that exactly where prostate cancer metastasizes to (outside of the prostate itself) is really important to how long a patient might reasonably expect to survive once metastasis is evident. This is why patients with higher-risk disease get both a bone scan and a CT scan at diagnosis. … READS MORE –

Lowering risk of death from prostate cancer AND cardiovascular disease

Based on a specific case study, a new paper in Circulation by a group of clinicians at Vanderbilt University Medical Center describes their program designed to reduce risk of death from cardiovascular disease for prostate cancer patients on androgen deprivation therapy (ADT). … READ MORE …

Why exactly do married/partnered prostate cancer patients live longer than single ones?

Historic data have long suggested that men with prostate cancer who are in a stable, married (or a long-term “partnered”) relationship have better long-term survival than single males. … READ MORE …

Low PSA + Gleason 8 to 10 disease predictive of higher risk, worse survival

It has been hypothesized for some time that men diagnosed with a low PSA level (i.e., < 4.0 ng/ml) but a high Gleason score (of 8, 9, or 10) are at elevated risk for more advanced disease and a shorter survival time than some others. … READ MORE …

Guessing the future price of the next major breakthrough in prostate cancer treatment

In an article published on Monday September 28, in Pharmaceutical Executive (a well-known biopharmaceutical industry trade journal) a senior health care public relations executive recently laid out a detailed rationale for why the industry needs to do a better job … READ MORE …

Long-term survival of men initially diagnosed with advanced (Stage IV) prostate cancer

An article in the July issue of the journal Radiation Oncology, along with a commentary on the UroToday web site, provides us with some interesting insights about the long-term survival of patients initially diagnosed with more advanced forms of prostate cancer. … READ MORE …

Does radical prostatectomy really extend life … at least in Denmark?

A newly published paper in the Scandinavian Journal of Urology comes to the potentially controversial conclusion that “the gain in life expectancy” after surgical treatment by radical prostatectomy “is minimal” for Danish men with prostate cancer compared to the life expectancy of Danish men in general. … READ MORE …