Orteronel active as “switch” maintenance therapy after docetaxel chemotherapy

According to a presentation given at the European Cancer Congress, currently ongoing in Vienna, Austria, a small, recently completed Phase III trial has shown that orteronel (TAK-700) might have had some value in treatment of late stage prostate cancer after all. … READ MORE …

Takeda discontinues development of orteronel for advanced prostate cancer

As previously reported, Takeda’s orteronel (also known as TAK-700), which had been in  Phase III clinical trials in metastatic, castration-resistant prostate cancer (mCRPC), failed to demonstrate a survival benefit in either of the two pivotal trials. … READ MORE …

Sunday morning’s news from the ASCO annual meeting

We commented earlier on several of the prostate cancer presentations given this morning at the American Society for Clinical Oncology (ASCO) meeting — see here and here. However, there was another important paper presented this morning. … READ MORE …

Takeda unblinds trial of ortoronel (TAK-700) in post-chemo mCRPC

Takeda Pharmaceutical Co. has unblinded the Phase III clinical trial of ortoronel + prednisone in treatment of men with progressive, metastatic, castration-resistant prostate cancer (mCRPC) who had been previously treated with at least one cycle of docetaxel-based chemotherapy. … READ MORE …

New Phase III trial is testing ADT + bicalutamide vs. ADT + TAK-700

It has been brought to our attention that the Southwest Oncology Group (SWOG) has initiated a new, randomized, double-blind, multi-center, Phase III trial designed to compare androgen deprivation therapy (ADT) + bicalutamide (Casodex) to ADT + the investigational drug TAK-700 in men newly diagnosed with metastatic, hormone-sensitive prostate cancer. … READ MORE …

Takeda completes enrollment of patients for pivotal Phase III trials of orteronel in mCRPC

Although the company has made no formal announcement, we have been advised that Takeda has, in fact, completed enrollment of patients into the two pivotal Phase III clinical trials of orteronel (TAK-700) for the treatment of patients with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Problems with enrollment into ongoing Phase III trials of new drugs for men with mCRPC?

Has the clinical success of some new drugs started to affect enrollment in trials of others for advanced forms of prostate cancer? … READ MORE …

Impact of abiraterone prior to chemotherapy — maybe not 4 years, but …

A story on the Bloomberg.com web site gives information about a patient with castration-resistant prostate cancer (CRPC) who has had a zero-level PSA for 40 months since starting on a clinical trial of abiraterone actetate in early 2008. … READ MORE …

TAK-700 to start Phase III clinical trial in mCRPC

According to a media release earlier today, Millennium and its parent company Takeda Pharmaceutical have initiated a randomized, double-blind, multi-center, Phase III clinical trial of TAK-700 (to be known in the future as Ortoronel) for the treatment of patients with chemotherapy-naïve, metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Takeda to start Phase II trials of TAK-700

According to a media release issued earlier today, Takeda Pharmaceuticals and it’s wholly owned subsidiary, Millennium, are starting the Phase II portion of a Phase I/II clinical trial of TAK-700 in patients with advanced prostate cancer. … READ MORE …