Patient preference and type of chemotherapy for mCRPC

In another presentation from the ESMO meeting in  Madrid, Spain, Fizazi et al. presented data from the randomized CABA-DOC trial  exploring patients’ preferences for either docetaxel or cabazitaxel as a first-line form of chemotherapy. … READ MORE …

TAPS as a side effect of taxane-based chemotherapy in men with advanced prostate cancer

TAPS stands for “taxane acute pain syndrome”. It is a recognized side effect of treatment with taxanes like docetaxel and it is usually characterized by muscular pain (myalgia) and joint pain (arthralgia) that starts about 24 to 48 hours after taxane treatment and then lasts for up to about 7 days. … READ MORE …

Can TMPRSS2-ERG gene expression predict low response to taxane therapy?

Drugs like docetaxel and cabazitaxel (taxanes) are among the most active forms of treatment in the management of men with metastatic, castration-resistant prostate cancer (mCRPC), but they don’t work for everyone. … READ MORE …

How taxane chemotherapy works in prostate cancer

Researchers at Weill Cornell Medical Center claim to have worked out more precisely how taxane-based chemotherapy (using drugs like paclitaxel, docetaxel, and cabazitaxel) actually works … with particular reference to how it works in prostate cancer. … READ MORE …

The aggressive treatment of high-risk localized and node-positive prostate cancer

Long-term follow-up data have just been published from two studies designed to provide preliminary information on the potential use of very aggressive forms of treatment in men with high-risk categories of prostate cancer. … READ MORE …

Wednesday’s news reports: February 25, 2009 — Part 2

Our second report today deals with:

  • Soy isoflavone concentration in prostate cancer tissue
  • A new vitamin E ether analog and its activity in the laboratory
  • PSA “half-life” as a prognostic indicator for impact of hormone therapy
  • Apolipoprotein C-I: is it important hormone-refractory prostate cancer?
  • Chemotherapeutic sensitization and its possible impact on taxane therapy … READ MORE …