Family history, PSA testing, and risk for diagnosis with prostate cancer

A presentation at the ongoing annual meeting of the European Association of Urology (EAU), in London, England, has reported (perhaps unsurprisingly) that PSA testing for risk of prostate cancer based on family history alone is not a very good idea. … READ MORE …

And now … data from the PCLO trial at 15 years …

A new update on the prostate cancer outcomes of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial has given us a rather different interpretation of the meaning of the data from this trial — although whether that “meaning” actually has “meaning” is probably up for debate. … READ MORE …

Responsibilities unasked for and the role of the USPSTF

A commentary in this week’s issue of the New England Journal of Medicine provides some valuable, historical insight into how it was that the U.S. Preventive Services Task Force (USPSTF) ended up with responsibilities that many of its members never wanted. … READ MORE …

Suggestions of bias in decisions about who got biopsies in the SELECT trial

A re-analysis of data from men participating in the placebo arms of the Prostate Cancer Prevention Trial (PCPT) and the Selenium and Vitamin E Cancer Prevention Trial (SELECT) has suggested a problem with bias in decisions about who gets biopsies during certain types of clinical trial. … READ MORE …

Of politics, prostate cancer, screening, and editorial opinions

We don’t often refer to articles in what are primarily political publications like The Hill, but an OpEd in that journal this week did catch our attention, and not in a particularly good way either. … READ MORE …

The impact of the USPSTF recommendation against screening: another take

A research letter from the epidemiologists and statisticians at the American Cancer Society has just been published in JAMA Oncology. The full text of the research letter is available on line. … READ MORE …

Informed patient counseling and the effect on PSA testing

We know that a family history of prostate cancer and the presence of certain genetic/genomic markers are associated with increased risk for prostate cancer in general and for some types of clinically significant prostate cancer in particular. … READ MORE …