Does TRT really delay biochemical recurrence after radical prostatectomy (in selected patients)?

Some data presented a few weeks ago at the annual meeting of the European Association for Urology appear to have surprised not only the study’s authors, but pretty much everyone else as well. … READ MORE …

The post-treatment testosterone debate

Conventional wisdom (dating back to the 1940s) has long been that giving testosterone supplements to men who had been treated for prostate cancer is a really bad idea. … READ MORE …

Why do men get prostate cancer?

The answer to this question, some 70 to 80 years after we started to see if we could answer it, is still: “We haven’t got a clue.” But every so often people come up with a new or a revised hypothesis, and it can take years to work out whether each specific hypothesis is viable. … READ MORE …

Testosterone supplements and new AUA guidelines on management of testosterone deficiency

The increasingly widespread use of testosterone supplements has been of concern for many years. In particular, for men with a history of prostate cancer diagnosis, the appropriate use of testosterone supplementation has been a matter of special focus. … READ MORE …

More information about how BAT may work

We know that “cycling” prostate cancer patients on and off high doses on testosterone while they are on androgen deprivation therapy (ADT) appears to have significant therapeutic benefit in at least some patients (see, for example, here). … READ MORE …

BAT + enzalutamide: data from the RESTORE study

Just over a year ago we wrote up a commentary on this web site entitled, “Can bipolar cycling of testosterone really cure prostate cancer?” It dealt with what is known as “bipolar androgen therapy” or BAT and referred to a Phase II clinical trial known as the RESTORE study. … READ MORE …

TRT in treatment for hypogonadism and prostate cancer risk

Discussions about the pros and cons of testosterone replacement therapy (TRT) in relation to (a) stimulating risk for prostate cancer in men who have not been diagnosed and (b) recurrence of prostate cancer among men who have been diagnosed and treated often aren’t entirely clear about a very key factor. … READ MORE …

Testosterone replacement therapy and prostate cancer risk

A new article in the Journal of Clinical Oncology has further undermined the long-held belief that there was an inherently increased risk for prostate cancer among men who received treatment with testosterone replacement therapy (TRT) for low testosterone levels. … READ MORE …

Testosterone levels in patients on androgen deprivation therapy

For the past 40 years, the formal level of “effectiveness” of androgen deprivation therapy (ADT, also known as “hormone” therapy) for men treated for high-risk, progressive, and/or metastatic prostate cancer has been a serum testosterone level of < 50 ng/dl (equivalent to < 1.7 nmol/l). However, … READ MORE …

Low serum T and active surveillance: let’s look before we leap

A new report from a group of Italian researchers has suggested that circulating serum testosterone (T) levels in the blood may be a risk for upgrading and upstaging among men initially diagnosed with low-risk prostate cancer who are managed on active surveillance. … READ MORE …

The efficacy and safety of TRT in men with treated and untreated prostate cancer

As we have mentioned frequently before, the use of testosterone replacement therapy (TRT) in men diagnosed with and/or treated for prostate cancer has been highly controversial, and the data supporting a role for TRT in such patients has been limited. … READ MORE …

Is it possible that testosterone supplements could actually reduce risk for prostate cancer?

According to a report on the MedPage Today web site, three presentations given at the recently completed annual meeting of the American Urological Association addressed prostate cancer risk among men taking testosterone supplements. … READ MORE …

Testosterone treatment in aging men with hypogonadism

Testosterone levels tend to fall in most men as we age. This is hardly new information! An article this week in the New England Journal of Medicine suggests that treatment with testosterone gels is appropriate for aging men with low testosterone levels (hypogonadism). … READ MORE …

What else was in the news today?

Today’s news contained items that run the spectrum from the clinical value of tomatoes and lycopene via the cardiovascular side effects of LHRH agonists and antagonists to the question of whether proton beam radiation therapy is really cost-effective. So here are the “news shorts” for the day: … READ MORE …

The use of TRT in hypogonadal prostate cancer patients

We may be seeing the beginning of a real turning point in opinions about the role of testosterone replacement therapy (TRT) in men who have been treated for prostate cancer. … READ MORE …