Does TRT really delay biochemical recurrence after radical prostatectomy (in selected patients)?

Some data presented a few weeks ago at the annual meeting of the European Association for Urology appear to have surprised not only the study’s authors, but pretty much everyone else as well. … READ MORE …

The post-treatment testosterone debate

Conventional wisdom (dating back to the 1940s) has long been that giving testosterone supplements to men who had been treated for prostate cancer is a really bad idea. … READ MORE …

Why do men get prostate cancer?

The answer to this question, some 70 to 80 years after we started to see if we could answer it, is still: “We haven’t got a clue.” But every so often people come up with a new or a revised hypothesis, and it can take years to work out whether each specific hypothesis is viable. … READ MORE …

Testosterone supplements and new AUA guidelines on management of testosterone deficiency

The increasingly widespread use of testosterone supplements has been of concern for many years. In particular, for men with a history of prostate cancer diagnosis, the appropriate use of testosterone supplementation has been a matter of special focus. … READ MORE …

More information about how BAT may work

We know that “cycling” prostate cancer patients on and off high doses on testosterone while they are on androgen deprivation therapy (ADT) appears to have significant therapeutic benefit in at least some patients (see, for example, here). … READ MORE …

BAT + enzalutamide: data from the RESTORE study

Just over a year ago we wrote up a commentary on this web site entitled, “Can bipolar cycling of testosterone really cure prostate cancer?” It dealt with what is known as “bipolar androgen therapy” or BAT and referred to a Phase II clinical trial known as the RESTORE study. … READ MORE …

TRT in treatment for hypogonadism and prostate cancer risk

Discussions about the pros and cons of testosterone replacement therapy (TRT) in relation to (a) stimulating risk for prostate cancer in men who have not been diagnosed and (b) recurrence of prostate cancer among men who have been diagnosed and treated often aren’t entirely clear about a very key factor. … READ MORE …