New data shows that local prostate radiotherapy improves OS in some men with newly diagnosed, metastatic prostate cancer

New data from the ongoing STAMPEDE trial in the UK and Switzerland has now confirmed that ablative radiation of the prostate itself (debulking of the primary tumor) improves overall survival (OS) in men newly diagnosed with metastatic prostate cancer who have a low metastatic disease burden but not in those with higher burden of disease. … READ MORE …

ASTRO, ASCO, and AUA strongly endorse shortened course of IMRT for primary therapy

It will come as no surprise to our readers that moderately hypofractionated IMRT (first-line radiation delivered in 20 to 26 treatments or fractions instead of the conventional 40-44 fractions) has received strong endorsement from all of the major US organizations of physicians who treat prostate cancer. … READ MORE …

I-131-MIP-1095 to enter randomized, Phase II clinical trial

As we reported last year, a new radiopharmaceutical has entered the pack. … READ MORE …

No survival benefit to debulking the prostate with radiation in first randomized clinical trial

The term “debulking” denotes the radical treatment (via prostatectomy or radiation therapy) of the cancerous prostate — lmost always in newly diagnosed patients — after distant metastases have been discovered. … READ MORE …

Can stem cell therapy “cure” ED?

Data from eight patients in a small clinical trial have suggested that stem-cell therapy may be able to restore erectile function in men treated for prostate cancer by radical prostatectomy. … READ MORE …

Escalated radiation dose doesn’t improve 8-year overall survival in intermediate-risk men (but does it matter?)

Last week, we saw that escalated dose did not improve 10-year overall survival in high-risk men (see this link). The latest published findings of the randomized clinical trial (RTOG 0126) prove that 8-year overall survival was not improved in intermediate-risk men who received a higher radiation dose. … READ MORE …

PSA “bounces” after first-line radiation therapy

Perhaps the single most annoying “side effect” of radiation therapy for prostate cancer is not a side effect at all; it’s the periodic fluctuations in PSA, called “bounces,” that can occur for years after therapy. … READ MORE …