The Metastatic Prostate Cancer Project: an update

In May 2017 we first let you know about the start-up of the Metastatic Prostate Cancer Project, which was subsequently launched in January 2018. Prostate Cancer International is one of the founding partners — along with the Broad Institute and others — in the development and evolution of this project. … READ MORE …

NCCN releases updated guidelines on management of prostate cancer

As it does at least once a year, the National Comprehensive Cancer Network (NCCN) has just released version 1.2018 of its guidelines for physicians on the management of prostate cancer. … READ MORE …

The current role of sipuleucel-T in the management of advanced prostate cancer

A new review article has provided a detailed update on the current state of knowledge about the use of sipuleucel-T (Provenge®) in the treatment of advanced forms of prostate cancer. … READ MORE …

Other significant news from the ASCO annual meeting

We apologize for the slight delay in getting to other notable news from the annual meeting of the American Society for Clinical Oncology. (Other elements of the rest of life interfered.) However, here is the keypoint summary with links to the relevant abstracts: … READ MORE …

Educating the family doctor about prostate cancer management

The August 15 issue of American Family Physician — supposedly one of the most widely read medical journals in America — carried an article by Mohan and Schellhammer entitled “Treatment options for localized prostate cancer.” Unfortunately the full text of this article is not available on line for the average reader. … READ MORE …

From Partin tables to a Partin nomogram — a 2010 update

A multi-center research team has used data from > 7,300 radical prostatectomy patients treated between 2000 and 2005 at two major medical centers to construct a new “2010 Partin nomogram” to improve prediction of pathologic outcomes after radical surgery. … READ MORE …

Prostate cancer news update, Thursday, September 11

Today’s prostate cancer update includes information on:

  • The lack of any specific connection between prostate cancer risk and a history of sexually transmitted infection
  • A review of current issues in the management of “high risk” prostate cancer patients
  • The effect the Medicare Modernization Action on the use of orchiectomy as compared to LHRH agonist therapy
  • The impact of prostate cancer treatment and outcomes of treatment on couples … READ MORE …

Prostate cancer news update: Tuesday, 9 September

This morning’s news update deals with two newly published studies:

  • The relative effectiveness of two different types of artificial sphincter for the chronically incontinent post-treatment
  • The impact of ADT on metabolic and cardiovascular processes and the risk for significant adverse reactions as a consequence of hypogonadism … READ MORE …

“Entertainment” education about prostate cancer screening

The ability to provide engaging and easily understood information about prostate cancer screening for low literacy popuations is a continuing challenge. Volk et al. have developed and evaluated an “entertainment-based” patient decision aid for prostate cancer screening, comparing its effectiveness among patients with low and high health literacy. … READ MORE …

EBRT for prostate cancer and increased risk for colon cancer?

A recent report by Rapiti et al. from the Geneva Cancer Registry documents a significant increase in risk for colon but not rectum cancer after earlier external beam radiotherapy (EBRT) for prostate cancer. While it is well known that radiotherapy can induce second cancers, there has been some controversy over the risk for second malignancies after irradiation for prostate cancer. … READ MORE …

Blood calcium levels and prostate cancer risk

A Reuters report issued today quotes US-based researchers as saying that men with elevated levels of calcium in their blood may have a much higher risk of getting fatal prostate cancer than the average man with a diagnosis of prostate cancer. … READ MORE …

What’s hot today? Tuesday, September 2

Today’s reports address:

  • The potential prognostic significance of a tertiary Gleason pattern in pathologic analysis of prostate cancer stage following a radical prostatectomy
  • The relative safety of two types of external beam radiotherapy in treatment of patients with localized prostate cancer … READ MORE …

Prostate cancer news update: Monday, September 1

In today’s reports:

  • Zoledronic acid (Zometa) has confirmed it’s impact on skeletal strength in the “real world”
  • Time to recovered of “normal” testosterone levels after ADT has been measured in a prospective clinical trial
  • Acupuncture appear to work to relieve “hot flashes” in men on LHRH agonists … READ MORE …

Cell Genesys halts VITAL-2 GVAX trial

In another severe setback for the application of immunotherapy in the treatment of advanced prostate cancer, Cell Genesys has announced the early termination of the Phase III VITAL-2 clinical trial comparing GVAX + docetaxel to docetaxel + prednisone. … READ MORE …

Two more new drugs enter Phase II trials for androgen-independent prostate cancer

ImClone Systems has announced the initiation of enrollment of patients with androgen-independent prostate cancer (AIPC) in a Phase II clinical trial with either IMC-A12 or IMC-1121B plus mitoxantrone and prednisone. … READ MORE …