Numbers progressing and time to progression on active surveillance

A new study just published in the World Journal of Urology has provided us with data from the Prostate Cancer Outcomes Registry — Victoria (in Australia) on the progression of men initially managed on active surveillance. … READ MORE …

Active surveillance, upgrading on repeat biopsy, and consequent management

In February this year we commented on an article that argued in favor of active surveillance as an appropriate initial management strategy for “favorable” intermediate-risk prostate cancer. … READ MORE …

Risk for prostate cancer grade “progression” (from Gleason 6 to Gleason 7 or higher)

We know that men initially diagnosed with Gleason 6 disease can (relatively frequently) be re-diagnosed later on with Gleason 7 disease or a higher Gleason score if they are on active surveillance protocols — although we often don’t know why this happens. … READ MORE …

Nomograms projecting risk for upgrading in lower-risk forms of prostate cancer

We are starting to see the development of nomograms that can be used to project the risk for future upgrading of men who are diagnosed with very low- and low-risk prostate cancer and who initially meet criteria for active surveillance as a first-line management strategy. … READ MORE …

Upgrading after re-biopsy in the Sunnybrook active surveillance cohort

In another key paper to be presented at the Genitourinary Oncology Symposium in Orlando tomorrow, Klotz and his colleagues have provided data on the rate of pathological upgrading at re-biopsy in their large cohort of patients on active surveillance at the Sunnybrook Health Sciences Center in Toronto. … READ MORE …

Predicting risk for Gleason score upgrades in non-surgical patients

The ability to predict risk for Gleason score upgrading in patients who have any form of treatment other than radical prostatectomy can be important, because it may help treating physicians and their patients to optimize first-line therapy. … READ MORE …

Prostate cancer news reports: Friday, December 11, 2009

Today’s news reports comment on:

  • Prostate cancer incidence in Asia vs. the West
  • PSA density as a risk factor for upgrading after surgery
  • The mechanisms of progression of CRPC … READ MORE …