INO-5150 in early treatment of biochemically recurrent prostate cancer

In 2015, Inovio Pharmaceuticals started a Phase I trial of INO-5150 — a new type of immunotherapy using a DNA vaccine for prostate cancer which targets both prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA). … READ MORE …

New form of vaccine therapy — for low-risk prostate cancer

According to a media report on the MarketWatch web site, a company called OncBioMune is to initiate Phase II clinical trials of a new type of prostate cancer vaccine (ProscaVax). … READ MORE …

New prostate cancer vaccine makes it through Phase Ia trial

A company called OncBioMune Pharmaceuticals has announced initial data from a Phase Ia/Ib clinical trial of a new form of vaccine in the treatment of men with progressive prostate cancer who meet the following criteria: … READ MORE …

Prostvac-type vaccine therapy in progressive prostate cancer after first-line therapy

A study just published in European Urology has suggested that early therapy with Prostvac-type vaccines might have value in the management of men with a rising PSA after first-line therapy. … READ MORE …

CureVac starts Phase IIb trial of CV9104

A German company called CureVac GmbH has started Phase IIb clinical trials of another cancer “vaccine” for men with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Is possible new prostate cancer vaccine really “promising”?

A new article on the Medscape Oncology web site (and again correlated with a media release sent out by the European Association for Urology [EAU] from their annual meeting in Milan, Italy) is headed “Prostate cancer vaccine shows promise.” However, the degree of that “promise” appears to be open to some question. … READ MORE …

University of Iowa starts Phase II trials with Ad/PSA vaccine

A research team at the University of Iowa is seeking patients to enroll in Phase II clinical trials of a new form of vaccine immunotherapeutic to treat men with recurrent prostate cancer. … READ MORE …

Are “universal” cancer vaccines feasible and clinically effective?

The idea that we might be able to use a single therapeutic “vaccine” to treat patients with  many different types of cancer is not new … and has yet to be substantiated in any large clinical trial. However, … READ MORE …

ProstAtak, Theragene, and the evolution of “vaccine-like” therapies for prostate cancer

In May this year we initially commented on a media announcement about a new form of vaccine-like therapy that was entering Phase III clinical trials for the first-line treatment of intermediate- and high-risk prostate cancer. … READ MORE …

New vaccine supposedly “cures prostate cancer in mice”

Now curing prostate cancer in mice absolutely does not necessarily imply that the same vaccine can be used to “cure prostate cancer in man,” … but the technical capability is certainly a step in the right direction (if it really is true). … READ MORE …

New Phase III trial of “gene suicide therapy” in localized prostate cancer

A biopharmaceutical company called Advantagene, Inc. announced last Thursday that it has reached agreement with the U.S. Food and Drug Administration regarding the conduct of a Phase III clinical trial of a vaccine-like treatment called ProstAtak™ — in combination with standard therapy — in the treatment of patients with newly diagnosed prostate cancer. … READ MORE …

On the feasibility of a “universal” cancer vaccine (but first in prostate cancer)

As some readers may be aware, one of the great biologic discoveries of the late 20th Century was the association between the length of the telomere (a piece of repeating DNA at the tips of each chromosome) and the ability of an individual cell to divide and replicate. … READ MORE …

AE37 shows initial activity in Phase I prostate cancer trial

Research into new “vaccine” immunotherapies for prostate cancer continues to be a hot topic following the approval of Dendreon’s Provenge just 3 weeks ago. … READ MORE …

New data on prostate cancer vaccine BPX-101

Straight from a “late-breaking poster” at the annual meeting of the Association for the Advancement of Cancer Research going on in Washington, DC, comes data about BPX-101 — another dendritic cell-based immunotherapeutic “vaccine” for the possible treatment of late-stage prostate cancer. … READ MORE …

Another new vaccine starts Phase I clinical trials

We have heard that another investigational vaccine therapy has started Phase I clinical trials that will include patients with advanced prostate cancer who “have failed at least 1 course of an accepted hormonal therapy.” … READ MORE …