A specific subset of men with a specific genetic variation respond to non-steroidal CYP17A1 inhibition

Just over a year ago, we reported on a paper by Hearn et al. that had shown that a specific inherited mutation in the HSD3B1 gene seemed to be associated with a more aggressive form of prostate cancer that was less responsive to treatment with androgen deprivation therapy (ADT). … READ MORE …

Understanding better how genetic variation may affect prostate cancer risk

Previous research using so-called “genome-wide association studies” or GWAS have suggested that there may be as many as 30 different inherited prostate cancer genetic risk variants. What we don’t know much about yet is the relationships between specific genetic risk variants and the clinical outcomes of patients carrying those variants. … READ MORE …

Genetic variant “associated” with aggressive as compared to indolent forms of prostate cancer

Another new article in the Proceedings of the National Academy of Sciences has suggested the possibility of major progress in the prostate cancer research field — but at least this time the media seem to have got the story right! … READ MORE …

More genetic variants associated with prostate cancer

Two new papers published on line in Nature Genetics have added a total of nine more genetic variants to the number of variants associated with an increased risk for prostate cancer. … READ MORE …