It was true 3 years ago, but is it still the case?

One of the problems with a lot of research is that it is out of date by the time it is published. The following example may be a classic case in point. And it has serious implications. … READ MORE …

The value in personalization of expectant management strategies

A recent and truly excellent review in Nature Reviews: Urology offers us a very thoughtful set of insights on the role of “expectant” and “conservative” management (i.e., active surveillance and watchful waiting) in the care of men with prostate cancer today. … READ MORE …

Expectant management is really “coming of age” in the USA

An excellent new review article in CA: A Cancer Journal of Clinicians, along with a research letter just published in the Journal of the American Medical Association (JAMA) have provided us with an important update on the value and the increasing acceptance of expectant management in the treatment of lower-risk forms of prostate cancer. … READ MORE …

Slow but increasing uptake of observation in initial management of low-risk patients

A new article by Maurice et al. in the Canadian Urological Association Journal provides detailed information about the use of initial observation as a management strategy for low-risk prostate cancer between 2004 and 2011. … READ MORE …

New draft Australian guidelines (on screening and expectant management)

A group of Australian experts has just released new draft guidance on prostate cancer screening and the role of expectant management (active surveillance and/or watchful waiting) in the management of prostate cancer. … READ MORE …

“Observation” in the management of low-risk prostate cancer

In an article in Recent Results in Cancer Research, Wilt argues (yet again)  that “observation” (i.e., something less than active surveillance and perhaps more like “watchful waiting”) is an entirely appropriate way to manage selected men with low-risk prostate cancer. … READ MORE …

The SPCG-4 trial: follow-up data after > 23 years

This week’s New England Journal of Medicine contains data from a fifth update to the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) trial of radical prostatectomy vs. watchful waiting in “early” prostate cancer. … READ MORE …

Of cost, quality, and care for low-risk prostate cancer

A newly published study in the Annals of Internal Medicine has offered an analysis of the cost-effectiveness of “observation” as compared to immediate initial treatment for men diagnosed with low-risk, localized prostate cancer. … READ MORE …

More on expectant management for screening-detected prostate cancer

Many readers may be interested in an article on active surveillance and other forms of expectant management by Khurana and Stephenson that appears on the front page of the November issue of the AUA News. This article is based on a poster presented by Khurana et al. at the annual meeting of the American Urological Association earlier this year.

Quality of life after initial watchful waiting compared to immediate treatment

According to another publication based on data from the Physicians’ Health Study, “Quality of life outcomes in men who underwent delayed treatment after initially waiting were not worse than in men who underwent immediate treatment.” … READ MORE …

Watchful waiting vs. external beam radiation: 15-year data from a randomized trial

According to a report presented today at the annual meeting of the American Society for Radiation Oncology (ASTRO) in Miami Beach, Florida, men with localized prostate cancer who were treated 15 years ago with external beam radiation therapy had no significant survival benefit compared to men followed with watchful waiting. … READ MORE …

Long-term watchful waiting and quality of life outcomes (compared to immediate treatment)

A new study in the Journal of Urology reports data on a cohort of 125 patients enrolled in the Physicians’ Health Study (PHS) who elected to be managed with watchful waiting for a minimum of 1 year after their initial diagnosis and who were followed for an average (mean) of 7.3 years. … READ MORE …

Long-term QoL of men in the Scandinavian Prostate Cancer Group 4 clinical trial

In 1989 the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) started randomizing men with a clinically initiated diagnosis of localized prostate cancer to either watchful waiting or open radical prostatectomy as their primary treatment. A new paper has now addressed the long-term quality of life (QoL) of men in this study. … READ MORE …

Retrospective cohort analysis shows mortality benefit in prostate cancer (but there’s a big “however”)

A new report in European Urology may offer some insights into the value of large, retrospective data analyses as compared to multi-center, randomized clinical trials when it comes to the assessment of the effects of different first-line treatments on the management of clinically localized prostate cancer. … READ MORE …

NIH to run state-of-the-science conference on active surveillance

On December 5 to 7 this year, the National Institutes of Health (NIH) is to hold an NIH State-of-the-Science Conference on the role of active surveillance and watchful waiting in the management of men with supposedly localized prostate cancer. It is free and open to the public or it can be monitored by web cast. … READ MORE …