PORTOS: a gene signature that predicts salvage radiation success

Salvage radiation is curative in roughly half of all cases. There are many factors that contribute to an unfavorable prognosis, including waiting too long, high PSA and rapid PSA doubling time, adverse post-surgery pathology (stage, Gleason score, positive margins), and high Decipher or CAPRA-S scores. But, … READ MORE …

Extraprostatic extension (EPE) alone is not enough to justify adjuvant radiation

Patrick Walsh and Nathan Laurentschuk have just published an opinion piece in European Urology taking issue with the 2013 AUA/ASTRO recommendation that adjuvant radiation is indicated for men with a pathological finding of extraprostatic extension (EPE, stage pT3a) after surgery, regardless of the surgical margin status. … READ MORE …

Does early salvage radiation save lives?

Several studies have tried to address the issue of whether adjuvant radiation actually increases prostate cancer survival in the long term compared to waiting. … READ MORE …

Can salvage radiation therapy be safely and effectively completed in less time?

Salvage or adjuvant external beam radiation therapy for prostate cancer is usually a protracted affair, more so since we learned that a total dose of about 64 Gy to 70 Gy was needed to be effective in the salvage setting. … READ MORE …

The GEMCaP markers and the Kattan post-surgical nomogram

There is increasing concurrence that the addition of GEMCaP biomarker data may be able to improve the prognostic accuracy of the Kattan post-treatment nomogram. … READ MORE …