Salvage radiation dose: decision-making under uncertainty

A large, well-done, confirmed, randomized clinical trial (RCT) is the only evidence that proves that one therapy is better than other. According to current consensus, this is deemed “Level 1a” evidence. But this high level of evidence is seldom available. … READ MORE …

Major US insurer to cover use of HIFU for treatment of radiorecurrent prostate cancer

According to a media release issued on March 18 by EDAP TMS, the US healthcare insurance firm CIGNA has agreed to cover the use of high-intensity focal ultrasound (HIFU) as a second-line, salvage therapy for men with radiorecurrent prostate cancer. … READ MORE …

A PSMA-based PET scan can change SRT decisions

The new PSMA-based PET scans provide a way to locate exactly where the cancer has spread to after an unsuccessful prostatectomy. … READ MORE …

New study: adjuvant radiation therapy saves lives vs. salvage

A major new study adds to several other studies that show that, for men with adverse pathology, adjuvant radiation (ART) within 3 to 6 months of prostatectomy saves more lives compared to waiting until the PSA rises into the range of 0.1 to 0.5 ng/ml — salvage radiation (SRT). … READ MORE …

Salvage SBRT after radical prostatectomy

The University of California, Los Angeles (UCLA) has announced a new clinical trial using stereotactic body radiation therapy (SBRT) for treatment of recurrent prostate cancer after failure of initial prostatectomy. … READ MORE …

When can ADT be safely avoided with salvage radiation therapy?

Two randomized clinical trials (GETUG-AFU-16 and RTOG 9601) proved that adding at least some ADT to salvage radiation (SRT) improved outcomes. “Some ADT” was 6 months of goserelin acetate in the GETUG-AFU-16 trial, and 2 years of bicalutamide in the RTOG 9601 trial. … READ MORE …

Salvage whole pelvic radiation after cancerous pelvic lymph nodes have been found

Is it still worthwhile to attempt salvage radiation therapy (SRT) after positive pelvic lymph nodes (PLN) have been pathologically detected (stage pN1)? … READ MORE …