Mutation to inherited HSD3B1 gene associated with more aggressive form of prostate cancer

According to an article to appear in the September issue of The Lancet Oncology, some patients with aggressive prostate cancer are more likely to die earlier from their disease if they carry a specific testosterone-related genetic abnormality. … READ MORE …

Is a possible benefit from longer-term docetaxel-based chemotherapy real?

A new paper in JAMA Oncology has suggested that longer docetaxel-based chemotherapy may be associated with longer survival for at least some men being treated for metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Probability of remaining recurrence-free after salvage radiation

Nearly 10 years ago, in 2007, Stephenson et al. published a nomogram that predicted the probability of success of salvage radiation therapy (SRT) after post-prostatectomy biochemical failure. … READ MORE …

Let’s call this “new technology” what it is; it’s a form of HIFU

According to information in the Boston Herald earlier today, researchers at Brigham & Women’s Hospital in Boston (one of the main teaching hospitals associated with Harvard University) are testing a new form of technology to treat localized prostate cancer. … READ MORE …

Alas, … the surgery vs. radiation therapy war continues …

In what certainly appears to be the largest and most thorough meta-analysis published to date, the authors conclude that surgery is a more effective first-line treatment for localized prostate cancer than radiation therapy. However, … READ MORE …

Is ADT giving you Alzheimer’s disease? … Another look

Late last year we reported on a study in the Journal of Clinical Oncology that suggested the possibility of a link between androgen deprivation therapy (ADT) and the onset of Alzheimer’s disease. … READ MORE …

How early salvage radiation therapy can be used to prevent metastases and save lives

Several clinical trials have established that adjuvant radiation reduces the risk of biochemical recurrence, but only one trial looked at and demonstrated an improvement in metastasis-free survival and prostate cancer-specific survival. … READ MORE …

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