After long-term ADT … recovery of normal hormonal function?

A group of Spanish clinical researchers have reported recent data from a small study designed to address an unanswered question about the recovery of (relatively) normal hormonal function after completion of androgen deprivation therapy (ADT). … READ MORE …

Does long-term ADT really affect cognitive function or not?

After > 50 years of use of various forms of androgen deprivation therapy (ADT), we still don’t really have a clear idea of whether or the degree to which long-term, continuous ADT can affect cognitive function — although there is no doubt at all that many patients believe it does. … READ MORE …

Mutation to inherited HSD3B1 gene associated with more aggressive form of prostate cancer

According to an article to appear in the September issue of The Lancet Oncology, some patients with aggressive prostate cancer are more likely to die earlier from their disease if they carry a specific testosterone-related genetic abnormality. … READ MORE …

Is ADT giving you Alzheimer’s disease? … Another look

Late last year we reported on a study in the Journal of Clinical Oncology that suggested the possibility of a link between androgen deprivation therapy (ADT) and the onset of Alzheimer’s disease. … READ MORE …

For very high-risk patients, EBRT + BT is superior to surgery or EBRT only

A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT). … READ MORE …

Why inheriting a particular gene may be important for prostate cancer patients

An important poster that your sitemaster managed to “miss” at the recent ASCO meeting (because he was at another meeting while it was being presented) has just been discussed on the MedPage Today web site. … READ MORE …

Has TOAD resolved a real and long-standing question?

So TOAD stands for “Timing of Androgen Deprivation” and refers to a randomized, multi-center, Phase III trial carried out in Australia, New Zealand, and Canada between September 3, 2004, and July 13, 2012. … READ MORE …