Finasteride lowers risk for diagnosis with prostate cancer WITHOUT increased risk for prostate cancer-specific mortality

Something that most of us seem to have managed to “miss” at the American Urological Association (AUA) annual meeting in San Francisco in May was an update from Dr. Ian Thompson on the 25-year outcomes of the Prostate Cancer Prevention Trial (PCPT). It has the potential to be rather important! … READ MORE …

Swedish data support PCPT re-analysis: no increase in high-risk prostate cancer after use of 5-ARIs

Another study, just published in the British Medical Journal, appears to further debunk the idea that use of 5α-reductase inhibitors (5-ARIs) is associated with a significant increase in risk for development of high-grade prostate cancer. … READ MORE …

Finasteride prevents 30 percent of low-risk prostate cancers (with no added risk of mortality)

An article published today in the New England Journal of Medicine and based on a re-visitation of data from the Prostate Cancer Prevention Trial (PCPT) suggests that finasteride may prevent as many as 30 percent of cases of low-risk prostate cancer without any increase in mortality. … READ MORE …

5-ARIs and prostate cancer risk: one step forward; one step back

As is so often the case in medicine, data suggesting a positive finding from one study comes out at about the same time as data demonstrating exactly the opposite … and in prostate cancer this occurs all too frequently! … READ MORE …

Overall survival among participants in the Prostate Cancer Prevention Trial

The Prostate Cancer Prevention Trial (PCPT) showed that treatment with finasteride (a 5α-reductase inhibitor) could lower the number of prostate cancers diagnosed in the U.S. each year by about 25 percent. … READ MORE …

FDA updates risks of adverse effects from treatment with finasteride

The U.S. Food & Drug Adminstration (FDA), yesterday, issued a statement about modifications to the labeling (the product prescribing information) for the two branded formulations of finasteride: Propecia® (finasteride 1 mg) and Proscar® (finasteride 5 mg). These modifications to the product labeling may be relevant to some men with or at risk for prostate cancer. … READ MORE …

5α-Reductase inhibitors and risk for high-grade prostate cancer

Yesterday the US Food & Drug Administration (FDA) updated its guidance on the use of 5α-reductase inhibitors with specific reference to the risk that use of these products may be able to induce high-grade (and therefore high-risk) prostate cancer in a small subset of men treated with these agents. … READ MORE …