The politics of PSA testing

We continue to see a steady stream of articles in the cancer literature that appears to be designed to influence the thinking of the U.S. Preventive Services Task Force (USPSTF) as they reconsider the value of PSA testing in assessment of risk for prostate cancer. … READ MORE …

Is standardization of the PSA cutpoint for biochemical recurrence after surgery a good idea?

A paper just published in this month’s issue of the Journal of Urology has suggested that the true cutpoint for PSA levels indicative of biochemical recurrence in the highest number of patients is actually 0.4 ng/ml (as opposed to the oft-stated 0.2 ng/ml). … READ MORE …

The systemic problems of the PCLO trial of PSA screening

A Letter to the Editor published in this week’s issue of the New England Journal of Medicine has, yet again, pointed out that the US-based PCLO trial was badly flawed and was never, in fact, a trial of screening against no screening. … READ MORE …

PCPC3 notes revisions to USPSTF research plan on PSA screening

PCPC3 — the patient-centered prostate cancer collaborative coalition — has just issued a statement about the revised research plan issued by the U.S. Preventive Services Task Force (USPSTF) in reassessing the value of PSA screening for risk of prostate cancer. … READ MORE …

Another reason to love your “bounces”

PSA “bounces” are (relatively small) increases in a patient’s PSA level from a lowering level after completion of primary radiation therapy The size of such bounces can vary significantly — from as little as 0.1 ng/ml to as much as 2.0 ng/ml or more … and they can be very worrisome. … READ MORE …

Optimal nadir PSA after salvage cryotherapy for radiorecurrent prostate cancer

According to a new article in the Journal of Endourology, the authors have identified an optimal PSA nadir level after whole-gland salvage prostate cryoablation among patients with recurrent prostate cancer. … READ MORE …

Citrate concentrations in seminal fluid and risk for prostate cancer

Another paper to be presented as a late-breaking poster at the upcoming annual meeting of the American Urological Association in San Diego suggests that citrate concentrations in seminal fluid may be a more accurate marker for prostate cancer risk than PSA levels. … READ MORE …

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