We recently saw (see this link) that men diagnosed with a Gleason score (GS) of 9 or 10 had lower rates of metastasis and better prostate-cancer survival if … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 10, aggressive, Gleason, Treatment | 11 Comments »
Data from a new study reported in the British Medical Journal discusses a “polygenic hazard score” that can potentially be used to guide screening for aggressive prostate cancer (but only in men of European ancestry at this time). … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, data, genetic, genomic, predict, risk, testing | 2 Comments »
A new paper by an international group of researchers from several different centers has maybe identified a new way to differentiate accurately between indolent and aggressive forms of prostate cancer at time of initial diagnosis. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: aggressive, expression, EZH2, gene, indolent, risk, TOP2A | 1 Comment »
Recent media releases have provided initial information about new tests for “advanced”, BRCA mutation-associated and for “aggressive” forms of prostate cancer that need immediate intervention. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: advanced, aggressive, BRCA, risk, test | Leave a comment »
A newly published article in the Journal of the National Cancer Institute has suggested that men carrying a particular genetic mutation in the kallikrein 6 gene (KLK-6) have an increased risk for aggressive, clinically significant prostate cancer. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, genetic, kallikrein, KLK-6, mutation, risk | 2 Comments »
So the results from the CHAARTED and STAMPEDE trials over the past few years have re-ignited debate over the appropriateness of early use of chemotherapy in the treatment of aggressive forms of prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: "high risk", aggressive, chemotherapy, early, outcomes | 1 Comment »
A newly published article in Prostate Cancer and Prostatic Diseases has (potentially) expanded our understanding of the role of saturated fats in men’s diets and consequent risk for diagnosis with aggressive forms of prostate cancer. … READ MORE …
Filed under: Diagnosis, Prevention, Risk | Tagged: aggressive, diet, fat, race, risk, saturated, unsaturated | Leave a comment »
According to an article to appear in the September issue of The Lancet Oncology, some patients with aggressive prostate cancer are more likely to die earlier from their disease if they carry a specific testosterone-related genetic abnormality. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: ADT, aggressive, gene, HSD3BI, LESS, responsive | 2 Comments »
Data just published in BJU International have recently suggested that men with a known, positive family history of prostate cancer are certainly at increased risk of low-grade prostate cancer compared to men with no known family history — but not at increased risk of aggressive prostate cancer. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, Diagnosis, family history, risk, screening | 1 Comment »
A paper just published in Cancer Research suggests that a particular ETS-negative subtype of prostate cancer (ERG−MAP3K7delCHD1del) is highly aggressive, and that coordinate loss of the MAP3K7 and CHD1 genes are potentially a unique driver of development of aggressive prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: aggressive, mortality, risk, subtype | 4 Comments »
A new study published on line in the journal Cancer has shown that (a) the cancer-specific survival benefit associated with aggressive treatment for early-stage prostate cancer is reduced with increasing co-morbidity at time of diagnosis, and (b) patients with Charlson scores ≥ 3 gain no survival benefit from aggressive treatment. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: aggressive, Charlson, Co-morbidity, early, mortality, risk, score, Treatment | Leave a comment »
According to a new article published in the May 12 issue of Cancer Cell, researchers believe that they have been able to identify a specific combination of two genes that, acting synergistically, may be the drivers behind some aggressive subtypes of prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Risk | Tagged: aggressive, CENPF, FOXM1, genes | 1 Comment »
We have now been able to track down a link to detailed information about the article by Yu et al. referred to in yesterday’s commentary under the same heading. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, CNV, copy number variation, progression, risk | 2 Comments »
