Posted on July 11, 2018 by Sitemaster
We recently saw (see this link) that men diagnosed with a Gleason score (GS) of 9 or 10 had lower rates of metastasis and better prostate-cancer survival if … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 10, aggressive, Gleason, Treatment | 11 Comments »
Posted on July 5, 2018 by Sitemaster
Last week we learned of a distinctly unusual case of advanced prostate cancer, and the patient has given us his permission to provide our readers with some specific information about his case. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: advanced, aggressive, cutaneous, metastatic | 4 Comments »
Posted on January 13, 2018 by Sitemaster
Data from a new study reported in the British Medical Journal discusses a “polygenic hazard score” that can potentially be used to guide screening for aggressive prostate cancer (but only in men of European ancestry at this time). … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, data, genetic, genomic, predict, risk, testing | 2 Comments »
Posted on September 22, 2017 by Sitemaster
A new paper by an international group of researchers from several different centers has maybe identified a new way to differentiate accurately between indolent and aggressive forms of prostate cancer at time of initial diagnosis. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: aggressive, expression, EZH2, gene, indolent, risk, TOP2A | 1 Comment »
Posted on June 21, 2017 by Sitemaster
Recent media releases have provided initial information about new tests for “advanced”, BRCA mutation-associated and for “aggressive” forms of prostate cancer that need immediate intervention. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: advanced, aggressive, BRCA, risk, test | Leave a comment »
Posted on March 17, 2017 by Sitemaster
A newly published article in the Journal of the National Cancer Institute has suggested that men carrying a particular genetic mutation in the kallikrein 6 gene (KLK-6) have an increased risk for aggressive, clinically significant prostate cancer. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, genetic, kallikrein, KLK-6, mutation, risk | 2 Comments »
Posted on November 17, 2016 by Sitemaster
So the results from the CHAARTED and STAMPEDE trials over the past few years have re-ignited debate over the appropriateness of early use of chemotherapy in the treatment of aggressive forms of prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: "high risk", aggressive, chemotherapy, early, outcomes | 1 Comment »
Posted on October 14, 2016 by Sitemaster
A newly published article in Prostate Cancer and Prostatic Diseases has (potentially) expanded our understanding of the role of saturated fats in men’s diets and consequent risk for diagnosis with aggressive forms of prostate cancer. … READ MORE …
Filed under: Diagnosis, Prevention, Risk | Tagged: aggressive, diet, fat, race, risk, saturated, unsaturated | Leave a comment »
Posted on August 29, 2016 by Sitemaster
According to an article to appear in the September issue of The Lancet Oncology, some patients with aggressive prostate cancer are more likely to die earlier from their disease if they carry a specific testosterone-related genetic abnormality. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: ADT, aggressive, gene, HSD3BI, LESS, responsive | 2 Comments »
Posted on October 19, 2015 by Sitemaster
Data just published in BJU International have recently suggested that men with a known, positive family history of prostate cancer are certainly at increased risk of low-grade prostate cancer compared to men with no known family history — but not at increased risk of aggressive prostate cancer. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, Diagnosis, family history, risk, screening | 1 Comment »
Posted on March 16, 2015 by Sitemaster
A paper just published in Cancer Research suggests that a particular ETS-negative subtype of prostate cancer (ERG−MAP3K7delCHD1del) is highly aggressive, and that coordinate loss of the MAP3K7 and CHD1 genes are potentially a unique driver of development of aggressive prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: aggressive, mortality, risk, subtype | 4 Comments »
Posted on May 14, 2014 by Sitemaster
A new study published on line in the journal Cancer has shown that (a) the cancer-specific survival benefit associated with aggressive treatment for early-stage prostate cancer is reduced with increasing co-morbidity at time of diagnosis, and (b) patients with Charlson scores ≥ 3 gain no survival benefit from aggressive treatment. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: aggressive, Charlson, Co-morbidity, early, mortality, risk, score, Treatment | Leave a comment »
Posted on May 13, 2014 by Sitemaster
According to a new article published in the May 12 issue of Cancer Cell, researchers believe that they have been able to identify a specific combination of two genes that, acting synergistically, may be the drivers behind some aggressive subtypes of prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Risk | Tagged: aggressive, CENPF, FOXM1, genes | 1 Comment »
Posted on May 8, 2012 by Sitemaster
We have now been able to track down a link to detailed information about the article by Yu et al. referred to in yesterday’s commentary under the same heading. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: aggressive, CNV, copy number variation, progression, risk | 2 Comments »
Posted on May 7, 2012 by Sitemaster
A new article in Nature Communications has suggested that we may be able to specifically identify some aggressive forms of prostate cancer cells that come with high risk for metastatic prostate cancer even at low PSA levels and other less aggressive forms of prostate cancer cell. … READ MORE …
Filed under: Diagnosis, Drugs in development, Risk | Tagged: aggressive, MAN2C1, metastasis, PSA, PTEN, recurrence | 1 Comment »