PREDICT Prostate: a new, sophisticated, prostate cancer prognostic tool

A new paper just published in PLOS Medicine describes the development of a new online tool called PREDICT Prostate. … READ MORE …

Can MRI data improve older, pre-treatment, prognostic methods?

An obvious but previously unanswered question has been whether adding data from the results of MRI scans to the data used in the Partin tables and in the pre-surgical Kattan nomogram (also known as the Memorial-Sloan Kettering Cancer Center or MSKCC nomogram) can improve the accuracy of these two commonly used prognostic methods. … READ MORE …

Probability of remaining recurrence-free after salvage radiation

Nearly 10 years ago, in 2007, Stephenson et al. published a nomogram that predicted the probability of success of salvage radiation therapy (SRT) after post-prostatectomy biochemical failure. … READ MORE …

The dangers of using nomograms to compare apples to oranges

A cross-specialty group of prostate cancer experts has reviewed data from > 13,000 patients on the accuracy of nomograms in predicting biochemical recurrence and actual prostate cancer-specific mortality after three different types of treatment. … READ MORE …

Predicting outcomes after early salvage radiation therapy for locally recurrent disease

A international, collaborative research group has but together a new nomogram designed to project outcomes at 5 years after early salvage radiation therapy (eSRT) for men with local disease recurrence after first-line surgery for localized prostate cancer. … READ MORE …

Can we accurately project risk for over-diagnosis and over-treatment?

There is an interesting new article just published in the Journal of the National Cancer Institute describing a nomogram designed to estimate risk for over-diagnosis of men diagnosed with prostate cancer. … READ MORE …

Nomograms projecting risk for upgrading in lower-risk forms of prostate cancer

We are starting to see the development of nomograms that can be used to project the risk for future upgrading of men who are diagnosed with very low- and low-risk prostate cancer and who initially meet criteria for active surveillance as a first-line management strategy. … READ MORE …

Clinical use of nomograms and other tools in prostate cancer counseling and prognosis

Clinical guidelines from such organizations as the American Urological Association (AUA) and the National Comprehensive Cancer Network (NCCN) call for measures designed to improve quality of care and facilitate better treatment decisions for men newly diagnosed with prostate cancer. The degree to which this really happens, however, is not well understood. … READ MORE …

Better defining appropriate candidates for active surveillance

A forthcoming paper from Tewari’s group at Weill Cornell Medical College in New York describes a new set of nomograms for assessment of risk for worsening prognosis in men with localized prostate cancer who might otherwise be considered appropriate candidates for management under active surveillance. … READ MORE …

Projection of 15-year prostate cancer-specific survival after radical prostatectomy

For several years we have been able to use the Kattan nomograms to project 5-, 7-, and 10-year recurrence-free survival before and after radical prostatectomy for localized prostate cancer, based on the patient’s age, stage, Gleason score, and other relevant data (associated with biopsy or surgical findings, as appropriate). … READ MORE …

From Partin tables to a Partin nomogram — a 2010 update

A multi-center research team has used data from > 7,300 radical prostatectomy patients treated between 2000 and 2005 at two major medical centers to construct a new “2010 Partin nomogram” to improve prediction of pathologic outcomes after radical surgery. … READ MORE …

Improving on the Kattan nomogram through use of genetic data

There is an interesting new paper forthcoming in the Journal of Urology in which the research team describes how the addition of data from genetic profiling is able to improve the accuracy of the Kattan pre-treatment nomogram specifically in men believed to have localized prostate cancer at the time of diagnosis. … READ MORE …

The GEMCaP markers and the Kattan post-surgical nomogram

There is increasing concurrence that the addition of GEMCaP biomarker data may be able to improve the prognostic accuracy of the Kattan post-treatment nomogram. … READ MORE …

15-year outcomes after radical prostatectomy: a new predictive model

An article just published by a highly respected group of specialists in the Journal of Clinical Oncology adds emphasis to the problem faced by patients newly diagnosed with low- or intermediate-risk localized prostate cancer. … READ MORE …

Prostate cancer news reports: Sunday, June 26, 2009

Today’s news reports address:

  • A new nomogram for predicting outcomes after brachytherapy
  • Results of a Phase III trial of combined androgen blockade in Japan … READ MORE …