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A forthcoming paper from Tewari’s group at Weill Cornell Medical College in New York describes a new set of nomograms for assessment of risk for worsening prognosis in men with localized prostate cancer who might otherwise be considered appropriate candidates for management under active surveillance.
Filed under: Diagnosis, Management, Risk | Tagged: active surveillance, candidate, nomogram, prognosis, risk | 9 Comments »
For several years we have been able to use the Kattan nomograms to project 5-, 7-, and 10-year recurrence-free survival before and after radical prostatectomy for localized prostate cancer, based on the patient’s age, stage, Gleason score, and other relevant data (associated with biopsy or surgical findings, as appropriate).
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 15-year, Kattan, mortality, nomogram, PCSM, prediction, projection, prostate cancer-specific, radical prostatectomy, surgery | 36 Comments »
A multi-center research team has used data from > 7,300 radical prostatectomy patients treated between 2000 and 2005 at two major medical centers to construct a new “2010 Partin nomogram” to improve prediction of pathologic outcomes after radical surgery.
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: nomogram, Partin tables, revision, update | 3 Comments »
There is an interesting new paper forthcoming in the Journal of Urology in which the research team describes how the addition of data from genetic profiling is able to improve the accuracy of the Kattan pre-treatment nomogram specifically in men believed to have localized prostate cancer at the time of diagnosis.
Filed under: Diagnosis, Management, Risk, Uncategorized | Tagged: gene, Kattan, nomogram, pre-treatment, prognosis | Leave a Comment »
There is increasing concurrence that the addition of GEMCaP biomarker data may be able to improve the prognostic accuracy of the Kattan post-treatment nomogram.
Filed under: Living with Prostate Cancer, Management | Tagged: biomarker, GEMCaP, Kattan, nomogram, post-surgical, prognosis | Leave a Comment »
An article just published by a highly respected group of specialists in the Journal of Clinical Oncology adds emphasis to the problem faced by patients newly diagnosed with low- or intermediate-risk localized prostate cancer.
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: mortality, nomogram, PCSM, prostate cancer-specific, radical prostatectomy | 7 Comments »
Today’s news reports address: A new nomogram for predicting outcomes after brachytherapy Results of a Phase III trial of combined androgen blockade in Japan
Filed under: Management, Treatment | Tagged: androgen deprivation, brachytherapy, combined, nomogram | Leave a Comment »
In today’s news reports we address new data on: The possible association between PSA levels and SNPs Patient age at diagnosis and prostate cancer outcomes Revalidation of the Stephenson nomogram for outcomes after salvage radiation therapy Failure to follow best practices for radiation of bony metastases
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment, Uncategorized | Tagged: age, best practices, Diagnosis, external beam radiation, nomogram, PSA, salvage, single nucleotide polymorphism, SNP | Leave a Comment »
In this commentary we will discuss four additional, significant papers presented yesterday in the major oral session on new prostate cancer studies.
Filed under: Living with Prostate Cancer, Management, Treatment, Uncategorized | Tagged: androgen deprivation, conservative management, nomogram, risk, survival | Leave a Comment »
There has been hope in some quarters that the prostate cancer gene 3 or PCA3 test would provide data so helpful that we could dispense with the need for PSA testing at all. However, The “New” Prostate Cancer Infolink has long suspected — for a variety of reasons — that this would not be the [...]
Filed under: Diagnosis, Risk | Tagged: nomogram, PCA3, pre-biopsy, value | 7 Comments »
We have added information about three more recent studies for your weekend reading, dealing with: Soy, diet, and prostate cancer prevention Outcomes of bladder neck preservation during radical prostatectomy A predictive model for chemotherapy outcomes in HRPC patients
Filed under: Drugs in development, Management, Prevention, Treatment | Tagged: bladder neck preservation, chemotherapy, diet, hormone-refractory prostate cancer, nomogram, outcome, Prevention, risk, soy | Leave a Comment »
Our third report today covers such topics as: A positive biopsy risk nomogram for men in New Zealand A review of current trends and priorities in surgical technique for radical prostatectomy A review of the potential of functional MRI-based systems for the diagnosis of prostate cancer Demonstration of a relationship between circulating tumor cells and [...]
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: biopsy, blood, circulating tumor cells, CTCs, Diagnosis, DNA, functional, IMRT, MRI, New Zealand, nomogram, radical prostatectomy, risk, technique, treatment planning | Leave a Comment »
The second set of reports in today’s news commentaries encompasses new nomograms, possible new biomarkers, a specific subtype of prostate cancer, and the “hedgehog” signaling pathway.
Filed under: Drugs in development, Living with Prostate Cancer, Management, Treatment | Tagged: biomarkers, ETS fusion, hedgehog signaling, ionized serum calcium, nomogram, recurrence, surgeon experience, survival | Leave a Comment »
An international group has developed and validated a new nomogram designed to predict the probability of early biochemical recurrence after radical prostatectomy (RP). Early identification of patients at risk for recurrence may improve prognosis because early institution of adjuvant therapy may reduce the risk of progression.
Filed under: Management, Treatment | Tagged: early biochemical recurrence, nomogram, post-RP | Leave a Comment »
In addition to commentary on papers by Eden et al. and by Porter et al., dealt with separately, other reports today address: The use of PSA in prostate cancer screening by UK-based urologists The predictive accuracy of nomograms (e.g., the Kattan nomogram) and A review of the cardiovascular and metabolic side effects of long-term ADT
Filed under: Uncategorized | Tagged: androgen deprivation, nomogram, PSA, screening, UK | Leave a Comment »
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