Death of al Megrahi — but was it of prostate cancer at all?

Acccording to an article on the Medscape web site today, the convicted “Lockerbie bomber,” Abdelbaset al Megrahi, finally died on Sunday, 2 years and 9 months after his release from a Scottish prison on compassionate grounds because he was close to dying of terminal prostate cancer. … READ MORE …

USPSTF makes unsophisticated “final” decision about role of PSA testing

According to an article in  today’s Annals of Internal Medicine, the U.S. Preventive Services Task Force or USPSTF has confirmed its prior draft recommendation against all “routine” use of PSA testing for risk of prostate cancer, stating that ”This recommendation applies to men in the general U.S. population, regardless of age.” … READ MORE …

Do SPOP mutations define a new molecular subtype of prostate cancer?

A Letter to the Editor just published in the journal Nature Genetics has suggested that that so-called SPOP mutations may be responsible for between 6 and 15 percent of the prostate cancers diagnosed in the USA each year. … READ MORE …

Update on Phase III trial of tasquinimod in mCRPC

According to a media release issued this morning by Active Biotech and Ipsen, the companies have already enrolled 600 out of the 1,200 men with metastatic, castration-resistant prostate cancer (mCRPC) needed to complete the randomized, double-blind Phase III clinical trial of tasquinimod. … READ MORE …

Living through chemotherapy (if you have to have it)

There is a “nice” post today about surviving chemotherapy on Dr. Craig Hildreth’s cancer blog on the CancerNetwork.com web site. (“Nice” is in inverted commas because not much about chemotherapy is actually nice … but if you, your oncologist, and the oncologist’s office team think about chemo in the way Dr. Hildreth describes, it sure as heck can help!)

Nothing to do with prostate cancer (yet), but …

According to an article by Andrew Pollack in today’s issue of the New York Times, a company called Osisris Therapeutics has achieved the first-ever approval to market a therapy based on stem cells — in Canada, for children with a condition known as graft versus host disease or GvHD, which is a well-recognized complication of bone marrow transplantation. … READ MORE …

Hospital volume important to outcomes among older, sicker, Medicare patients treated by RP

A media release issued by Henry Ford Health System earlier today has a distinctly misleading headline that reads as follows: “Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery.” You need to read the content of the media release with care to understand that this headline is by no means an accurate summation of the results of the study referred. … READ MORE …

NICE issues new and positive draft guidance on abiraterone acetate

According to information on the web site of the National Institute for Clinical Excellence (NICE), revised draft guidance has been issued by NICE regarding the routine use of abiraterone acetate. … READ MORE …

Abiraterone acetate may help to eliminate cancer prior to surgery in some men with high-risk, localized disease

According to the abstract of a paper to be presented at the upcoming meeting of the American Society for Clinical Oncology in Chicago at the beginning of June, 24 weeks of treatment with neoadjuvant abiraterone acetate + prednisone + an LHRH agonist appears to be able to eliminate visible risk of prostate cancer in post-surgical specimens in a small percentage of men diagnosed with high-risk disease. … READ MORE …

Abiraterone in the UK: rumors are rife …

According to recent articles in the media, the National Institute for Clinical Excellence (NICE) will shortly issue a recommendation that abiraterone is covered for routine use in the UK among men with chemotherapy-refractory, metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

Wanna learn about being a consumer/patient reviewer for the DoD PCRP?

On Wednesday this week, you can join an hour-long webcast at which Dr. Carolyn Best and a colleague from the Department of Defense Prostate Cancer Research Program (DoD PCRP) will explain what is involved and how to apply. Sign yourself up right NOW! … READ MORE …

DNA methylation and the aggressiveness of prostate cancer

According to a media release from the Mayo Clinic earlier today, “Alterations to the ‘on-off’ switches of genes occur early in the development of prostate cancer and could be used as biomarkers to detect the disease months or even years earlier than current approaches.” … READ MORE …

PBRT vs. IMRT — are we about to get the definitive trial?

According to an article in the Boston Globe this morning, we are (supposedly and finally) going to get the study needed to try to demonstrate whether there is a real clinical benefit to proton beam radiation therapy as compared to modern, intensity-modulated radiation therapy in men with localized prostate cancer! … READ MORE …

Expert video-discussion on evolution in the management of late stage prostate cancer

Here is a link to a recent 20-minute video-discussion on the Medscape web site between an number of European experts on evolutions in the management of castration-resistant (and earlier forms of) prostate cancer. … READ MORE …

NICE rejects “routine” use of cabazitaxel in UK

According to a media release issued today by the National Institute for Clinical Excellence (NICE) in the UK, the institute’s advisory board will not recommend “routine” use of cabazitaxel for the treatment of metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …

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